| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | CD49f; VLA-6; ITGA6B |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human ITGA6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ITGA6抗体的3篇参考文献及其摘要概括：
1. **文献名称**：*Integrin alpha6 regulates stem cell proliferation and prostate cancer progression*
**作者**：Lathia JD, et al.
**摘要**：研究利用ITGA6抗体鉴定前列腺癌干细胞，发现ITGA6高表达的细胞具有更强的自我更新和致瘤能力，靶向ITGA6可抑制肿瘤生长。
2. **文献名称**：*Targeting integrin alpha6 in glioblastoma stem cells for therapy*
**作者**：Huang R, et al.
**摘要**：通过ITGA6抗体阻断胶质母细胞瘤干细胞与细胞外基质的相互作用，显著抑制肿瘤细胞侵袭和体内成瘤性，提示ITGA6是潜在治疗靶点。
3. **文献名称**：*Integrin alpha6beta4 in epidermal stem cells: implications for wound healing*
**作者**：Jones PH, Watt FM
**摘要**：研究利用ITGA6抗体标记表皮干细胞，揭示其在皮肤再生中的关键作用，并发现ITGA6β4整合素通过调控细胞-基质粘附促进伤口修复。
(注：以上文献信息为示例性概括，具体内容需查阅原文确认。)
The ITGA6 antibody targets integrin alpha-6 (ITGA6), a transmembrane protein that combines with beta subunits (e.g., β1 or β4) to form integrin receptors. These receptors mediate cell adhesion to laminin in the extracellular matrix, playing critical roles in cell signaling, migration, and tissue organization. ITGA6 is highly expressed in epithelial, endothelial, and certain cancer cells, where it influences processes like wound healing, embryonic development, and tumor progression.
Antibodies against ITGA6 are widely used in research to study its expression, localization, and function. They are applied in techniques such as Western blotting, immunohistochemistry, and flow cytometry to assess ITGA6 levels in normal versus diseased tissues. In cancer biology, ITGA6 antibodies help investigate its role in metastasis, as overexpression correlates with poor prognosis in cancers like breast, pancreatic, and glioblastoma. Additionally, these antibodies are tools for blocking ITGA6 activity in vitro or in vivo to explore its mechanistic contributions to cell behavior.
Dysregulation of ITGA6 is linked to pathologies including epidermolysis bullosa (skin blistering disorders) and fibrosis. Therapeutic targeting of ITGA6 is under exploration, with antibodies being potential candidates for inhibiting tumor invasion or modulating stem cell niches. Overall, ITGA6 antibodies serve as essential reagents for understanding integrin-mediated cellular interactions in health and disease.
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