| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | pf16; Repro-SA-1 |
| WB Predicted band size | 55 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human SPAG6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于SPAG6抗体的参考文献及其简要摘要：
1. **文献名称**: *SPAG6 regulates cell proliferation and apoptosis via the Akt pathway in non-small cell lung cancer*
**作者**: Li Y, et al.
**摘要**: 该研究利用SPAG6抗体通过免疫组化和Western blot检测非小细胞肺癌(NSCLC)中SPAG6蛋白的表达，发现其高表达与Akt信号通路激活相关，促进肿瘤细胞增殖并抑制凋亡。
2. **文献名称**: *Expression and functional analysis of SPAG6 in mouse testis and sperm*
**作者**: Zhang Y, et al.
**摘要**: 研究通过免疫荧光和免疫印迹技术，使用SPAG6抗体定位小鼠睾丸和精子中的SPAG6蛋白，证实其在精子鞭毛形成中的关键作用，基因敲除导致雄性不育。
3. **文献名称**: *SPAG6 is a potential prognostic marker in colorectal cancer by modulating cell migration*
**作者**: Wang H, et al.
**摘要**: 利用SPAG6抗体分析结直肠癌组织样本，发现SPAG6高表达与患者不良预后相关，并通过体外实验证明其通过调控细胞骨架蛋白影响肿瘤细胞迁移能力。
(注：以上文献信息为模拟示例，实际引用需查询具体数据库。)
The SPAG6 (Sperm-Associated Antigen 6) antibody is a tool used to detect and study the SPAG6 protein, a member of the sperm-associated antigen family. SPAG6 is primarily recognized for its role in spermatogenesis, where it contributes to the structural and functional integrity of sperm flagella by interacting with microtubules. Structurally, SPAG6 contains a conserved microtubule-binding domain and is implicated in regulating ciliary and flagellar motility. Beyond reproductive biology, SPAG6 has been linked to various cancers, including lung, liver, and ovarian cancers, where its aberrant expression may correlate with tumor progression, metastasis, or poor prognosis. This dual relevance in reproductive and cancer biology makes SPAG6 a protein of broad research interest.
The SPAG6 antibody is widely utilized in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate SPAG6 expression patterns, localization, and interactions in tissues or cell lines. Studies employing this antibody have shed light on SPAG6's involvement in cellular processes like cell cycle regulation, apoptosis, and motility. In clinical contexts, SPAG6 antibodies are explored for potential diagnostic or prognostic applications, particularly in male infertility and cancer. However, variations in antibody specificity, epitope recognition, and experimental conditions necessitate careful validation to ensure reliable results. Ongoing research continues to clarify SPAG6's multifaceted roles and therapeutic potential.
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