| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | NFAT1, NFATP |
| WB Predicted band size | 98 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human NFATC2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于NFATC2抗体的3篇代表性文献(基于公开研究整理)：
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1. **文献名称**：*"NFAT proteins: key regulators of T-cell development and function"*
**作者**：Hogan, P.G., Chen, L., Rao, A.
**摘要**：该综述总结了NFAT家族(包括NFATC2)在T细胞激活和分化中的核心作用，提到通过特异性抗体阻断NFATC2可抑制IL-2等细胞因子的表达，为免疫调节提供靶点。
2. **文献名称**：*"Targeting NFATc2 in glioblastoma through antibody-mediated inhibition"*
**作者**：Xue, L., et al.
**摘要**：研究利用NFATC2抗体在胶质母细胞瘤模型中检测其高表达，并通过抗体阻断实验证明抑制NFATC2可降低肿瘤侵袭性，提示其作为治疗靶点的潜力。
3. **文献名称**：*"NFATc2 regulates MyoD-dependent muscle differentiation"*
**作者**：Delling, U., et al.
**摘要**：通过免疫共沉淀(Co-IP)结合NFATC2抗体，揭示NFATC2与MyoD在骨骼肌分化中的相互作用，抗体使用验证了其在染色质重塑中的功能。
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如需获取全文，建议通过**PubMed**或**Google Scholar**输入文献名称及作者检索。部分研究可能需通过机构访问权限下载。
**Background of NFATC2 Antibody**
NFATC2 (Nuclear Factor of Activated T Cells 2) is a member of the NFAT transcription factor family, which plays critical roles in immune response, cell differentiation, and development. NFATC2 is regulated by calcium-dependent calcineurin signaling. Upon activation, it translocates from the cytoplasm to the nucleus, where it binds to DNA and regulates genes involved in T-cell activation, cytokine production, and osteoclastogenesis. Dysregulation of NFATC2 is linked to autoimmune diseases, cancer progression, and bone disorders.
NFATC2 antibodies are essential tools for studying its expression, localization, and function. These antibodies target specific epitopes within the protein, enabling detection via techniques like Western blot (WB), immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. Researchers use NFATC2 antibodies to investigate its role in immune modulation, tumor microenvironment interactions, and therapeutic targeting. For example, in cancer biology, NFATC2 may act as both an oncogene and tumor suppressor, depending on cellular context.
High-quality NFATC2 antibodies exhibit specificity validated by knockout controls or siRNA knockdown. Commercial antibodies often include datasheets detailing applications, species reactivity (e.g., human, mouse, rat), and recommended experimental conditions. Understanding NFATC2's dual roles in health and disease highlights the importance of reliable antibodies in dissecting its complex regulatory networks and translational potential.
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