| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | NGX6, NAG-5, C9orf127, RP11-112J3.10 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human TMEM8B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TMEM8B抗体的3篇参考文献示例(注：部分文献信息为虚构，仅供格式参考)：
1. **"Development and characterization of a polyclonal antibody against human TMEM8B for cancer biomarker studies"**
*Authors: Zhang, L., et al. (2018)*
**摘要**：本研究报道了一种兔源多克隆抗体的开发，通过免疫原性肽段合成与纯化获得。该抗体成功用于Western blot和免疫组化检测TMEM8B在多种癌症组织中的表达，发现其在结直肠癌中显著下调，提示其潜在肿瘤抑制功能。
2. **"TMEM8B antibody-based profiling reveals its role in neuronal differentiation"**
*Authors: Chen, Y., & Wang, H. (2020)*
**摘要**：利用商业化TMEM8B单克隆抗体，研究者发现该蛋白在小鼠脑发育过程中高表达，并通过siRNA敲低实验证明TMEM8B通过调控Wnt/β-catenin通路影响神经干细胞分化，为神经发育障碍研究提供新靶点。
3. **"Validation of a novel TMEM8B monoclonal antibody in autoimmune disease models"**
*Authors: Gupta, S., et al. (2021)*
**摘要**：文章验证了一种高特异性小鼠单克隆抗体(克隆号4D2)，证实其适用于流式细胞术与免疫荧光。研究显示TMEM8B在类风湿性关节炎患者外周血单核细胞中表达异常，可能参与炎症反应调控。
(注：实际文献需通过PubMed/Google Scholar等数据库检索确认。)
The TMEM8B antibody is a research tool designed to detect and study the transmembrane protein 8B (TMEM8B), a member of the conserved transmembrane protein family. TMEM8B, also known as CXorf27. is encoded by the TMEM8B gene and is characterized by its multi-pass transmembrane structure, though its precise biological function remains under investigation. Current studies suggest its involvement in cellular processes such as membrane dynamics, cell adhesion, and signaling pathways. Dysregulation of TMEM8B has been implicated in various pathologies, including cancer, neurodevelopmental disorders, and infectious diseases, highlighting its potential role in disease mechanisms.
The TMEM8B antibody is widely utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to analyze protein expression, localization, and interaction partners. Its development often involves validation in knockout (KO) models or siRNA-mediated knockdowns to confirm specificity. Researchers employ this antibody to explore TMEM8B's tissue-specific expression patterns, particularly in neural tissues and immune cells, and to investigate its association with pathways like Wnt/β-catenin or autophagy. Recent studies also link TMEM8B to viral entry mechanisms, sparking interest in therapeutic targeting. As a reagent, the antibody supports both basic research and translational studies aiming to elucidate TMEM8B's role in health and disease, potentially paving the way for diagnostic or therapeutic innovations.
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