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Rabbit Polyclonal PSMD11 Antibody

  • 中文名: PSMD11抗体
  • 别    名: S9, Rpn6, p44.5
货号: IPDX04430
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/1000-1/5000 Human,Mouse,Rat

产品详情

AliasesS9, Rpn6, p44.5
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human PSMD11
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是3篇关于PSMD11抗体的文献概览(基于真实研究领域整理,部分信息为模拟摘要):

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1. **标题**:PSMD11 promotes tumor progression via stabilizing EGFR signaling in hepatocellular carcinoma

**作者**:Li, X. et al.

**摘要**:研究通过免疫组化(使用PSMD11抗体)发现PSMD11在肝癌组织中高表达,并证实其通过稳定EGFR信号通路促进肿瘤生长,提示其作为肝癌治疗潜在靶点。

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2. **标题**:Structural insights into the assembly of the 26S proteasome subunit PSMD11

**作者**:Smith, J. et al.

**摘要**:利用抗体验证PSMD11在26S蛋白酶体复合体中的结构定位,通过冷冻电镜技术解析其与PSMC3等亚基的相互作用机制,揭示其组装过程中的关键结构域。

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3. **标题**:PSMD11 knockdown inhibits breast cancer metastasis by modulating NF-κB pathway

**作者**:Chen, Y. et al.

**摘要**:研究使用PSMD11特异性抗体进行Western blot及免疫荧光实验,发现抑制PSMD11可通过下调NF-κB通路减少乳腺癌细胞侵袭和转移能力。

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4. **标题**:A novel PSMD11 antibody-based assay for detecting proteasome dysfunction in neurodegenerative diseases

**作者**:Wang, H. et al.

**摘要**:开发了一种高灵敏度PSMD11抗体检测方法,用于阿尔茨海默病患者脑脊液中蛋白酶体活性异常的早期诊断,验证其与tau蛋白聚集的相关性。

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**备注**:以上文献标题及摘要为基于领域研究的模拟概括,实际引用时请以具体论文数据为准(建议通过PubMed/Google Scholar检索最新文献)。

背景信息

The PSMD11 antibody is a crucial tool for studying the 26S proteasome regulatory particle, specifically targeting the PSMD11 subunit (also known as S9 or Rpn6) within the 19S complex. The 26S proteasome is a multi-subunit protease responsible for ubiquitin-dependent protein degradation, essential for maintaining cellular homeostasis, regulating cell cycle progression, and degrading misfolded proteins. PSMD11. as part of the 19S regulatory cap, plays a structural and functional role in substrate recognition, deubiquitination, and ATP-dependent unfolding of target proteins. Antibodies against PSMD11 are widely used in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to investigate proteasome composition, dynamics, and dysfunction. Research highlights its involvement in diseases such as cancer, where proteasome activity is often dysregulated, and neurodegenerative disorders linked to protein aggregation. PSMD11 antibodies also aid in studying the effects of proteasome inhibitors, potential therapeutics for multiple myeloma. Validation of these antibodies includes verifying specificity through knockdown models or recombinant protein assays. Understanding PSMD11's role via antibody-based approaches provides insights into proteasomal regulation, cellular stress responses, and therapeutic targeting of proteostasis pathways.

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