| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ANTP; HOX1; HOX1A; HOX1.1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human HOXA7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于HOXA7抗体的3篇参考文献示例(注：内容为虚构，仅作格式参考)：
---
1. **文献名称**: *HOXA7 Expression in Ovarian Cancer: Correlation with Tumor Progression*
**作者**: Zhang L, et al.
**摘要**: 本研究利用HOXA7特异性抗体通过免疫组化技术，发现HOXA7在高级别浆液性卵巢癌中显著高表达，并与患者预后不良相关，提示其可能作为潜在生物标志物。
2. **文献名称**: *HOXA7 Antibody Validation for Epigenetic Studies in Breast Cancer*
**作者**: Smith JR, et al.
**摘要**: 文章系统验证了HOXA7抗体在Western blot和ChIP-seq中的特异性，证实HOXA7通过调控EMT通路促进乳腺癌侵袭，为表观遗传机制研究提供可靠工具。
3. **文献名称**: *Developmental Role of HOXA7 in Neural Crest Cells Revealed by Immunohistochemistry*
**作者**: Tanaka K, et al.
**摘要**: 通过HOXA7抗体标记技术，揭示了HOXA7在小鼠胚胎神经嵴细胞迁移中的时空表达模式，表明其对颅面发育具有关键调控作用。
---
(注：以上文献信息为模拟生成，实际引用需查阅真实数据库如PubMed。)
The HOXA7 antibody is a crucial tool in studying the HOXA7 protein, a member of the homeobox (HOX) gene family, which plays pivotal roles in embryonic development, cellular differentiation, and tissue patterning. HOX genes, highly conserved across species, encode transcription factors that regulate body segment identity along the anterior-posterior axis. HOXA7. located on chromosome 7p15.2. is involved in developmental processes, including limb formation, organogenesis, and hematopoiesis. Dysregulation of HOXA7 has been implicated in various cancers (e.g., leukemia, breast, and ovarian cancers), where its aberrant expression correlates with tumor progression, metastasis, or therapeutic resistance.
HOXA7 antibodies are typically designed to detect specific epitopes of the protein via techniques like Western blotting, immunohistochemistry (IHC), or immunofluorescence (IF). They enable researchers to investigate HOXA7's spatial-temporal expression, subcellular localization (primarily nuclear), and interactions with downstream targets. Commercially available antibodies are often validated for specificity using knockout cell lines or siRNA-mediated silencing. Challenges include cross-reactivity with homologous HOX proteins due to conserved homeodomains, necessitating careful validation. Studies utilizing these antibodies have shed light on HOXA7's dual roles—acting as an oncogene or tumor suppressor depending on context—and its potential as a diagnostic or prognostic biomarker. Recent research also explores HOXA7 in non-cancer contexts, such as wound healing and neurodevelopment, expanding its biomedical relevance.
×
