| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | AX2R; AXIIR; C5orf39 |
| WB Predicted band size | 22 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human ANXA2R |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ANXA2R抗体的模拟参考文献示例(仅供参考，具体文献需通过学术数据库验证)：
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1. **"Targeting ANXA2R with a Novel Monoclonal Antibody Suppresses Tumor Metastasis in Murine Models"**
*Authors: Smith A, et al.*
**摘要**：本研究开发了一种靶向ANXA2R的单克隆抗体，通过体外和体内实验证明其能有效抑制肿瘤细胞的迁移和侵袭。机制研究表明，抗体通过阻断ANXA2R与胞外基质的相互作用，降低基质金属蛋白酶活性，从而抑制转移。
2. **"ANXA2R Autoantibodies in Systemic Autoimmune Diseases: Diagnostic and Prognostic Implications"**
*Authors: Zhang L, et al.*
**摘要**：文章分析了ANXA2R自身抗体在系统性红斑狼疮(SLE)和抗磷脂综合征(APS)患者中的表达，发现其与血栓形成和疾病活动度显著相关，提示其作为潜在生物标志物的价值。
3. **"Neutralizing ANXA2R Antibodies Inhibit HIV-1 Entry by Disrupting Viral-Cell Membrane Fusion"**
*Authors: Brown K, et al.*
**摘要**：研究利用ANXA2R中和抗体阻断HIV-1与宿主细胞的膜融合过程，证实ANXA2R在病毒入侵中的关键作用，为抗病毒治疗提供新策略。
4. **"Development of a High-Affinity Anti-ANXA2R Antibody for Imaging Tumor Vasculature"**
*Authors: Lee J, et al.*
**摘要**：团队开发了一种高亲和力抗体，结合分子成像技术，成功可视化肿瘤血管中的ANXA2R表达，为癌症诊断和治疗评估提供新工具。
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**注意**：以上文献为模拟示例，实际研究中请通过PubMed、Web of Science等平台检索关键词(如ANXA2R antibody、anti-ANXA2R therapy)获取真实文献。
The Annexin A2 receptor (ANXA2R), also known as AXIIR or p11. is a cell-surface protein that binds Annexin A2 (ANXA2), a calcium-dependent phospholipid-binding protein involved in membrane organization, vesicle trafficking, and extracellular proteolysis. ANXA2R facilitates the interaction of ANXA2 with tissue plasminogen activator (tPA) and plasminogen, playing a key role in fibrinolytic activity and cell surface proteolysis. This receptor is implicated in diverse physiological processes, including angiogenesis, cell migration, and immune response regulation.
In pathological contexts, ANXA2R is often overexpressed in cancers (e.g., breast, pancreatic, glioblastoma) and associated with tumor progression, metastasis, and therapeutic resistance. Its role in promoting plasmin generation contributes to extracellular matrix degradation, facilitating invasive behavior. ANXA2R antibodies are critical tools for studying these mechanisms, enabling detection of receptor expression in tissues or cell lines via techniques like immunohistochemistry, flow cytometry, or Western blot. Researchers also use blocking antibodies to inhibit ANXA2R-ANXA2 interactions, exploring their therapeutic potential in cancer and thrombotic disorders. However, ANXA2R's dual roles in homeostasis and disease necessitate context-specific evaluation. Recent studies highlight its involvement in viral entry (e.g., SARS-CoV-2) and autoimmune diseases, expanding its biomedical relevance. Validated antibodies with high specificity remain essential for clarifying its multifunctional biology and translational applications.
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