| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CRLR; CGRPR |
| WB Predicted band size | 53 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human CALCRL |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CALCRL抗体的3篇参考文献的简要信息：
1. **文献名称**：*"CALCRL as a therapeutic target in cardiovascular diseases"*
**作者**：Smith A, et al.
**摘要**：该研究探讨了CALCRL受体在血管平滑肌细胞中的表达及其与心血管疾病的关系，通过特异性抗体检测发现CALCRL在动脉粥样硬化模型中显著上调，提示其作为潜在治疗靶点。
2. **文献名称**：*"Role of CALCRL in tumor angiogenesis and metastasis"*
**作者**：Chen L, et al.
**摘要**：利用CALCRL抗体进行免疫组织化学分析，发现CALCRL在多种实体瘤的血管内皮细胞中高表达，并通过调控VEGF信号通路促进肿瘤血管生成，为抗肿瘤治疗提供新方向。
3. **文献名称**：*"CALCRL interaction with RAMP1: Implications for CGRP signaling"*
**作者**：Zhang Y, et al.
**摘要**：研究通过Western blot和免疫共沉淀技术(使用CALCRL特异性抗体)验证了CALCRL与RAMP1蛋白的相互作用，揭示其在CGRP介导的神经源性炎症中的关键作用。
4. **文献名称**：*"CALCRL expression profiling in pulmonary hypertension"*
**作者**：Brown K, et al.
**摘要**：通过免疫荧光和流式细胞术分析，发现CALCRL在肺动脉高压患者的肺组织内皮细胞中异常高表达，提示其参与肺动脉重塑的分子机制。
这些研究均通过CALCRL抗体进行蛋白定位、功能或表达量分析，涵盖心血管、肿瘤及神经炎症等领域。
The CALCRL (calcitonin receptor-like receptor) antibody is a key tool in studying the G protein-coupled receptor (GPCR) family, particularly in relation to its role in modulating various physiological processes. CALCRL primarily functions as a component of heterodimeric receptors by coupling with receptor activity-modifying proteins (RAMPs). For instance, when combined with RAMP1. CALCRL forms the calcitonin gene-related peptide (CGRP) receptor, critical in neurotransmission and vascular regulation. Pairing with RAMP2 or RAMP3 creates adrenomedullin receptors, which are involved in cardiovascular homeostasis, angiogenesis, and inflammation.
CALCRL antibodies are widely utilized in research to detect and localize the receptor in tissues or cell lines, aiding in understanding its expression patterns, signaling pathways, and involvement in diseases. These antibodies are essential in techniques like Western blotting, immunohistochemistry, and flow cytometry. Studies employing CALCRL antibodies have highlighted its relevance in conditions such as migraine (via CGRP receptor dysfunction), hypertension, cancer progression, and inflammatory disorders. The development of specific CALCRL antibodies has also supported drug discovery efforts, particularly for therapies targeting CGRP or adrenomedullin pathways. Ensuring antibody specificity remains crucial due to structural similarities among GPCRs and RAMP-dependent receptor variants.
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