| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | AL4; CT4.7; GAGE7B; GAGE-7B |
| WB Predicted band size | 13 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human GAGE12I |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是基于学术文献特征的模拟示例，用于说明可能的GAGE12I抗体相关研究方向。请注意，这些文献信息为假设性示例，实际研究中可能存在差异：
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1. **文献名称**：*GAGE12I as a novel tumor-associated antigen in melanoma: Development of a monoclonal antibody for diagnostic use*
**作者**：Smith A, et al.
**摘要**：本研究报道了一种针对GAGE12I蛋白的高特异性单克隆抗体的开发，验证了其在黑色素瘤组织中的高表达，并探讨了其作为免疫组化诊断标志物的潜力。
2. **文献名称**：*Targeting GAGE12I with CAR-T cells: Preclinical evaluation in solid tumors*
**作者**：Zhang L, et al.
**摘要**：通过构建靶向GAGE12I的嵌合抗原受体(CAR-T)，作者证明了该抗体介导的细胞疗法在体外和小鼠模型中可有效抑制肺癌细胞生长，提示其免疫治疗应用前景。
3. **文献名称**：*Serum GAGE12I autoantibody as a prognostic biomarker in ovarian cancer*
**作者**：Johnson R, et al.
**摘要**：研究利用ELISA技术检测卵巢癌患者血清中抗GAGE12I自身抗体水平，发现其与肿瘤分期和生存率显著相关，提示其作为无创预后标志物的价值。
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**备注**：
- 实际研究中，GAGE家族成员(如GAGE1、GAGE12B等)的研究较多，但针对“GAGE12I”的特定文献可能有限，建议通过PubMed或Google Scholar以“GAGE family antibodies”或“GAGE12I + cancer”为关键词检索最新成果。
- 若需真实文献，请提供更具体的背景信息(如研究领域或应用场景)。
The GAGE12I antibody targets a member of the GAGE (G antigen) protein family, a group of cancer-testis antigens (CTAs) predominantly expressed in germline cells (e.g., testis, placenta) but aberrantly activated in various cancers. GAGE proteins, including GAGE12I, are characterized by a conserved PRAME-like structural domain and are implicated in tumorigenesis, immune evasion, and poor prognosis. Their restricted expression in normal tissues and reactivation in malignancies like melanoma, lung, and ovarian cancers make them attractive targets for immunotherapy and biomarker studies.
GAGE12I, encoded by the *GAGE12* gene cluster on chromosome X, shares homology with other GAGE family members but exhibits distinct expression patterns and potential functional roles. Studies suggest its involvement in regulating apoptosis, cell cycle progression, or epigenetic modifications, though exact mechanisms remain under investigation. Antibodies against GAGE12I are primarily utilized in research to detect its expression in tumor tissues, assess its diagnostic/prognostic relevance, and explore its role in cancer biology. Additionally, GAGE12I-specific antibodies support efforts to develop T cell-based therapies or vaccines targeting this antigen, leveraging its immunogenic properties. Despite therapeutic promise, challenges include addressing its low immunogenicity and ensuring tumor-specific targeting to minimize off-effects. Ongoing research aims to clarify its biological significance and translational potential in oncology.
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