| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | Adenosinetriphosphatase; ATP1B; ATP1B1; Atpb 1; ATPBS;;ATP1B1 |
| WB Predicted band size | Calculated MW: 35 kDa ; Observed MW: 40-50 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human ATP1B1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于LTB4R2抗体的3篇代表性文献摘要(文献标题和内容为示例性概括，具体文献需根据实际数据库检索确认)：
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1. **标题**：*Characterization of LTB4R2-Specific Antibodies and Their Role in Inhibiting Cancer Cell Migration*
**作者**：Yamada A, et al.
**摘要**：本研究开发了针对LTB4R2(白三烯B4受体2)的高特异性单克隆抗体，验证了其在结直肠癌细胞系中的结合能力。实验表明，阻断LTB4R2可显著抑制肿瘤细胞的迁移和侵袭，提示其在癌症治疗中的潜在应用。
2. **标题**：*LTB4R2 Expression in Inflammatory Macrophages: A Study Using Antibody-Based Immunoassay*
**作者**：Smith J, et al.
**摘要**：通过抗LTB4R2抗体的免疫组化与流式细胞术分析，发现LTB4R2在炎症微环境中的巨噬细胞表面高表达，且与促炎细胞因子(如IL-6、TNF-α)的释放密切相关，为炎症性疾病提供了治疗靶点。
3. **标题**：*Development of a Neutralizing Antibody Against LTB4R2 for Asthma Intervention*
**作者**：Chen L, et al.
**摘要**：研究团队筛选出一种中和性LTB4R2抗体，可有效阻断白三烯B4信号通路。动物模型显示，该抗体能减轻气道炎症和黏液分泌，为哮喘等呼吸系统疾病提供了新的干预策略。
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如需具体文献，建议通过PubMed或Web of Science以关键词“LTB4R2 antibody”或“BLT2 antibody”检索最新研究。
The leukotriene B4 receptor 2 (LTB4R2), also known as BLT2. is a G protein-coupled receptor (GPCR) that binds leukotriene B4 (LTB4), a potent lipid mediator involved in inflammatory and immune responses. LTB4R2 shares structural homology with LTB4R1 (BLT1) but exhibits distinct ligand affinities and tissue distribution. While LTB4R1 primarily mediates pro-inflammatory effects, LTB4R2 is activated by lower concentrations of LTB4 and other lipid metabolites, such as 12(S)-hydroxyheptadecatrienoic acid (12-HHT), suggesting a broader regulatory role in homeostasis and disease. It is expressed in various tissues, including the skin, intestines, and immune cells.
Antibodies targeting LTB4R2 are essential tools for studying its expression, localization, and function in physiological and pathological contexts. They enable detection via techniques like immunohistochemistry, Western blotting, and flow cytometry. Research using these antibodies has linked LTB4R2 to inflammatory disorders (e.g., psoriasis, asthma), cancer progression (e.g., breast, colon cancer), and tissue repair mechanisms. Some studies suggest LTB4R2 may exert anti-inflammatory or pro-resolving effects under certain conditions, contrasting its classical inflammatory role. Commercial LTB4R2 antibodies are validated for specificity across species, supporting translational research and drug development targeting LTB4 signaling pathways. However, functional variability across cell types and disease models underscores the need for context-dependent interpretation of findings.
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