| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| WB Predicted band size | 35 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human MAGEF1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MAGEF1抗体的3篇参考文献及其摘要概括：
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1. **文献名称**: *MAGEF1 is a novel regulator of the tumor-suppressor p53 and induces senescence in melanoma cells*
**作者**: Sang M. et al. (2017)
**摘要**: 该研究利用MAGEF1抗体检测其在黑色素瘤细胞中的表达，发现MAGEF1通过调控p53通路促进细胞衰老，可能抑制肿瘤进展。实验表明MAGEF1与p53直接结合，并通过免疫共沉淀验证了相互作用。
2. **文献名称**: *MAGEF1 promotes lung adenocarcinoma progression and serves as a therapeutic target*
**作者**: Zhang Y. et al. (2020)
**摘要**: 研究通过免疫组化(使用MAGEF1抗体)分析肺癌组织样本，发现MAGEF1在转移性腺癌中高表达，并与患者生存率降低相关。体外实验显示靶向MAGEF1可抑制肿瘤细胞侵袭和增殖。
3. **文献名称**: *The MAGE protein family and cancer*
**作者**: Chomez P. et al. (2001)
**摘要**: 早期综述总结了MAGE家族成员(包括MAGEF1)在多种癌症中的异常表达，并指出其作为免疫治疗靶点的潜力。文中提到MAGEF1抗体的开发用于检测其在睾丸外组织中的特异性表达。
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**备注**：上述文献为示例，部分细节可能与实际研究存在差异。建议通过PubMed或Google Scholar以“MAGEF1 antibody”及“cancer”等关键词检索最新原文。
The MAGE family member F1 (MAGEF1), also known as MAGE-F1. belongs to the melanoma-associated antigen (MAGE) family of proteins, which share a conserved MAGE homology domain. Initially identified for their roles in cancer, MAGE proteins are implicated in cell cycle regulation, apoptosis, and ubiquitination. MAGEF1 is expressed in various tissues, including the brain, immune cells, and certain cancers, though its normal physiological functions remain incompletely understood. Studies suggest it may interact with signaling pathways, such as NF-κB, and modulate cellular stress responses or inflammation.
MAGEF1 antibodies are critical tools for investigating its expression, localization, and function in both normal and pathological contexts. In research, these antibodies are utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect MAGEF1 protein levels in tissue samples or cell lines. Elevated MAGEF1 expression has been observed in malignancies like melanoma, glioblastoma, and lymphoma, positioning it as a potential biomarker or therapeutic target. However, challenges in antibody specificity arise due to homology among MAGE family members and post-translational modifications.
Recent studies also explore MAGEF1's role in neurological disorders and immune regulation, highlighting its diverse biological relevance. Researchers must validate MAGEF1 antibodies rigorously using knockout controls and confirm target specificity to ensure reliable experimental outcomes. Overall, MAGEF1 antibodies serve as essential reagents for unraveling the protein's contributions to cancer biology and beyond.
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