| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | P160; PAP2 |
| WB Predicted band size | 149 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human MYBBP1A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MYBBP1A抗体的示例参考文献(注：以下内容为示例性虚构，仅用于格式参考，实际文献需通过学术数据库检索)：
1. **文献名称**: *MYBBP1A regulates p53-mediated transcriptional activation in response to ribosomal stress*
**作者**: Sasaki, M., et al.
**摘要**: 本研究利用MYBBP1A特异性抗体，通过免疫共沉淀和染色质免疫沉淀(ChIP)技术，揭示了MYBBP1A在核仁应激条件下与p53结合并增强其转录活性的分子机制，为癌症治疗提供潜在靶点。
2. **文献名称**: *MYBBP1A interacts with NF-κB and modulates inflammatory gene expression*
**作者**: Sun, Y., et al.
**摘要**: 通过Western blot和免疫荧光实验，作者发现MYBBP1A抗体可特异性检测内源性蛋白，并证实MYBBP1A通过与NF-κB亚基p65相互作用，抑制炎症相关基因的表达。
3. **文献名称**: *MYBBP1A promotes rRNA processing and cell proliferation in breast cancer*
**作者**: Chen, L., et al.
**摘要**: 研究使用MYBBP1A抗体进行组织芯片分析，显示MYBBP1A在乳腺癌中高表达，并通过调控rRNA加工促进肿瘤细胞增殖，提示其作为预后标志物的潜力。
4. **文献名称**: *The role of MYBBP1A in oxidative stress-induced senescence*
**作者**: Mori, T., et al.
**摘要**: 利用MYBBP1A敲低和抗体验证实验，证明该蛋白通过抑制SIRT1去乙酰化酶活性，加剧氧化应激诱导的细胞衰老，为衰老相关疾病研究提供新视角。
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**建议**：实际文献可通过PubMed、Google Scholar等平台检索关键词“MYBBP1A antibody”或“MYBBP1A function”，筛选涉及该抗体应用的实验研究(如Western blot、IP、IHC等)。部分抗体厂商(如Abcam、Cell Signaling)的产品页面也可能提供相关引用文献。
MYBBP1A (Myb-binding protein 1A) is a nuclear protein that plays multifaceted roles in transcriptional regulation, ribosome biogenesis, and cellular stress responses. Initially identified as a binding partner of the Myb transcription factor, MYBBP1A functions as a scaffold or co-regulator, interacting with diverse proteins such as p53. NF-κB, and PREP1 to modulate gene expression. It localizes predominantly in nucleoli, where it participates in rRNA processing and ribosome assembly. MYBBP1A also acts as a stress sensor: under nucleolar stress, it translocates to the nucleoplasm, stabilizing p53 by disrupting its interaction with MDM2. thereby inducing cell cycle arrest or apoptosis. Dysregulation of MYBBP1A has been linked to cancer, developmental disorders, and neurodegenerative diseases, highlighting its importance in maintaining genomic stability and cellular homeostasis.
Antibodies targeting MYBBP1A are essential tools for investigating its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunofluorescence, chromatin immunoprecipitation (ChIP), and immunohistochemistry. These antibodies help elucidate MYBBP1A’s role in tumor suppression, its involvement in ribosomal stress pathways, and its regulatory crosstalk with oncogenic or tumor-suppressive signaling networks. Commercial MYBBP1A antibodies are typically raised in rabbits or mice, with validation across human, mouse, and rat samples. Their specificity and reliability make them critical for both basic research and clinical studies exploring MYBBP1A’s diagnostic or therapeutic potential.
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