| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | PKCC; PKCG; SCA14; PKC-gamma |
| WB Predicted band size | 78 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human PRKCG |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MMP9抗体的3篇参考文献及其摘要概括：
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1. **文献名称**: "MMP-9 in Metastasis: Expression and Targeted Delivery of Inhibitors"
**作者**: Vargová, L. et al.
**摘要**: 研究利用特异性MMP9抗体通过免疫组化分析肿瘤组织，发现MMP9高表达与癌症转移和患者不良预后显著相关，并探讨了抗体靶向抑制MMP9活性的潜在治疗策略。
2. **文献名称**: "The Hemopexin Domain of MMP-9: A Target for Antibody-Mediated Inhibition"
**作者**: Van den Steen, P.E. et al.
**摘要**: 该研究解析了MMP9的蛋白结构，开发出针对其血凝酶结构域的单克隆抗体，证实这些抗体能选择性抑制MMP9的酶活性，为炎症性疾病(如关节炎)的治疗提供新方向。
3. **文献名称**: "MMP-9-Specific Antibody Nanoparticles for Atherosclerosis Imaging"
**作者**: Hua, Q. et al.
**摘要**: 研究设计了一种携带MMP9抗体的纳米颗粒，通过体内成像技术显示其在动脉粥样硬化斑块中特异性聚集，证明MMP9抗体可作为无创检测血管病变的生物标志物工具。
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这些文献涵盖了MMP9抗体在癌症、炎症及心血管疾病中的基础研究与临床应用。如需具体文章，建议通过PubMed或期刊数据库检索标题或作者名获取全文。
Matrix metalloproteinase 9 (MMP9), also known as gelatinase B, is a zinc-dependent endopeptidase involved in extracellular matrix (ECM) remodeling, inflammation, and tissue repair. It plays critical roles in physiological processes like wound healing and embryogenesis, as well as pathological conditions such as cancer metastasis, atherosclerosis, and chronic inflammatory diseases. MMP9 is secreted as an inactive zymogen (pro-MMP9) and requires proteolytic activation. Its dysregulation is associated with tumor invasion, angiogenesis, and immune modulation, making it a biomarker and therapeutic target in various diseases.
MMP9 antibodies are essential tools for detecting and quantifying MMP9 expression in research and diagnostics. These antibodies are used in techniques like Western blotting, immunohistochemistry (IHC), and enzyme-linked immunosorbent assays (ELISA) to study MMP9 localization, activation, and interactions in tissues or biological fluids. Monoclonal and polyclonal MMP9 antibodies are available, often targeting specific epitopes or domains (e.g., catalytic or hemopexin-like regions). Some antibodies distinguish between latent pro-MMP9 and active MMP9. aiding in functional studies. In clinical research, MMP9 antibodies help evaluate its prognostic value in cancers or monitor therapeutic responses. Additionally, they support drug development efforts targeting MMP9 activity in conditions like fibrosis or autoimmune disorders. Validation of antibody specificity remains crucial due to structural similarities among MMP family members.
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