| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | p30; PRR6; CENP-V; 3110013H01Rik |
| WB Predicted band size | 30 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human CENPV |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CENPV抗体的示例参考文献(内容为模拟示例，仅供参考)：
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1. **文献名称**: *CENPV is a novel biomarker for hepatocellular carcinoma progression*
**作者**: Li X, et al.
**摘要**: 本研究通过免疫组化分析发现，CENPV在肝癌组织中高表达，其抗体特异性检测显示与患者预后不良相关，提示CENPV可能作为肝癌治疗的潜在靶点。
2. **文献名称**: *Development and validation of a polyclonal antibody against human CENPV for centromere function studies*
**作者**: Tanaka K, et al.
**摘要**: 文章报道了一种针对人源CENPV蛋白的多克隆抗体制备方法，并通过免疫荧光验证其在有丝分裂期间对着丝粒定位的特异性，为研究染色体分离机制提供工具。
3. **文献名称**: *Autoantibodies to CENPV in systemic sclerosis: Clinical correlations*
**作者**: Müller S, et al.
**摘要**: 该研究发现系统性硬化症患者血清中存在抗CENPV自身抗体，且与特定临床症状(如肺纤维化)显著相关，为疾病诊断提供了新生物标志物。
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**注意**：以上文献为示例，实际研究中请通过 **PubMed/Google Scholar** 等平台检索最新文献，关键词可尝试 "CENPV antibody" 或 "Centromere Protein V" + "antibody"。
CENPV (Centromere Protein V) is a key component of the centromere, a specialized chromosomal region essential for proper chromosome segregation during cell division. It localizes to the inner kinetochore plate and interacts with other centromeric proteins, such as CENP-A and CENP-C, to maintain centromere integrity and ensure accurate microtubule attachment. CENPV plays a role in stabilizing nucleosome structure and regulating mitotic progression, making it critical for genomic stability. Dysregulation of CENPV has been implicated in chromosomal instability disorders and cancer progression.
CENPV antibodies are widely used in research to study centromere architecture, kinetochore assembly, and cell cycle regulation. These antibodies enable the detection and localization of CENPV via techniques like immunofluorescence, western blotting, and chromatin immunoprecipitation (ChIP). They are particularly valuable in investigating diseases linked to centromere dysfunction, including certain cancers and autoimmune conditions (e.g., CREST syndrome), where abnormal centromere protein expression may serve as a diagnostic marker. Commercially available CENPV antibodies are typically raised against specific epitopes of human CENPV, with cross-reactivity tested in common model organisms. Validation includes verification of signal specificity through siRNA knockdown or knockout cell lines. Ongoing studies continue to explore CENPV's role in aging, meiosis, and targeted cancer therapies.
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