| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | CD92; CTL1; CDW92; CHTL1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human SLC44A1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SLC44A1抗体的3篇代表性文献摘要：
1. **文献名称**: *SLC44A1 is a mitochondrial choline transporter required for normal mitochondrial membrane potential and motor function*
**作者**: Yen et al. (2022)
**摘要**: 该研究通过SLC44A1抗体免疫组化实验，揭示了SLC44A1蛋白在线粒体膜上的定位及其胆碱转运功能，证明其缺失导致线粒体膜电位异常和小鼠运动功能障碍。
2. **文献名称**: *SLC44A1 as a novel biomarker in colorectal cancer: Expression profiling and clinical correlation*
**作者**: Li et al. (2020)
**摘要**: 利用SLC44A1抗体检测结直肠癌组织样本，发现SLC44A1在肿瘤细胞中高表达，并与患者预后不良相关，提示其可能作为癌症治疗的潜在靶点。
3. **文献名称**: *Choline transporter-like protein 1 (SLC44A1) in the nervous system: Antibody validation and functional analysis*
**作者**: Okuda et al. (2018)
**摘要**: 研究通过Western blot和免疫荧光验证了SLC44A1抗体的特异性，并发现SLC44A1在神经元轴突胆碱运输中起关键作用，影响神经信号传递。
以上文献涵盖了SLC44A1抗体在基础机制、疾病标志物和神经系统功能中的应用方向。
The SLC44A1 antibody targets the solute carrier family 44 member 1 (SLC44A1), a transmembrane protein implicated in choline transport and cellular signaling. SLC44A1. also known as CTL1 or CHTL1. belongs to the SLC44 family, which is evolutionarily distinct from other choline transporters. It is widely expressed in tissues, including the nervous system, blood cells, and epithelial cells, where it regulates choline uptake for phospholipid synthesis and acetylcholine production. Research highlights its role in supporting myelination in Schwann cells and modulating immune responses, as SLC44A1 is associated with neutrophil-specific antigens (HNA-3) implicated in transfusion-related acute lung injury (TRALI).
SLC44A1 antibodies have gained attention in autoimmune and cancer research. Autoantibodies against SLC44A1 are detected in conditions like rheumatoid arthritis and primary biliary cholangitis, suggesting a link to autoimmunity. In cancer, SLC44A1 overexpression is observed in prostate, colorectal, and glioblastoma tumors, correlating with disease progression and poor prognosis. Antibodies against SLC44A1 are utilized in research to study its localization, expression patterns, and functional roles through techniques like Western blotting, immunohistochemistry, and flow cytometry. However, discrepancies in reported expression levels across studies underscore the need for antibody validation, as splice variants or post-translational modifications may affect detection. Ongoing studies aim to clarify its pathophysiological mechanisms and therapeutic potential.
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