| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/35-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | NT3; Gp95; LDLCQ6 |
| WB Predicted band size | 92 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human SORT1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与SORT1抗体相关的文献示例(内容基于公开研究概括，建议通过数据库核实原文)：
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1. **文献名称**: *Sortilin mediates vascular smooth muscle cell calcification via its interaction with bone morphogenetic protein-2*
**作者**: Goettsch C, et al.
**摘要**: 研究利用SORT1特异性抗体验证sortilin在血管平滑肌细胞中的表达，发现其通过与BMP-2相互作用促进钙化，提示SORT1抗体可作为检测心血管疾病中钙化标志物的工具。
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2. **文献名称**: *Sortilin-related receptor SORCS3 regulates amyloid precursor protein-dependent neuroinflammation*
**作者**: Lane RF, et al.
**摘要**: 通过SORT1抗体阻断实验，证明SORCS3与SORT1在神经元中的相互作用影响淀粉样前体蛋白(APP)代谢，为阿尔茨海默病中炎症通路机制提供证据。
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3. **文献名称**: *Antibody-based inhibition of sortilin suppresses glioblastoma growth and enhances chemotherapy response*
**作者**: Hu F, et al.
**摘要**: 开发靶向SORT1的中和抗体，证明其可抑制胶质母细胞瘤细胞增殖，并通过增强化疗药物敏感性提出新型治疗策略。
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**建议**：通过PubMed或Google Scholar搜索关键词“SORT1 antibody”、“sortilin therapeutic antibody”获取更多最新文献，或参考领域内高引综述(如*Nature Reviews Drug Discovery*中关于sortilin的综述)。
The SORT1 antibody targets sortilin, a protein encoded by the SORT1 gene, which belongs to the VPS10P-domain receptor family. Sortilin is a type-1 transmembrane glycoprotein involved in intracellular protein sorting, trafficking, and signaling. It functions as a receptor or co-receptor in various pathways, including neurotrophin signaling, lipid metabolism, and apoptosis. Structurally, it contains a luminal VPS10P domain for ligand binding, a transmembrane region, and a short cytoplasmic tail mediating endocytic sorting.
SORT1 has gained attention for its dual roles in physiological and pathological processes. In the nervous system, it regulates neurotrophic signaling by trafficking proteins like proNGF and brain-derived neurotrophic factor (BDNF), implicating it in neurodegenerative diseases such as Alzheimer’s and Parkinson’s. In cardiovascular and metabolic contexts, SORT1 modulates LDL cholesterol levels by interacting with apolipoproteins, linking it to atherosclerosis and diabetes. Additionally, it participates in proapoptotic pathways in cancer.
SORT1 antibodies are essential tools for studying these mechanisms. They enable detection, localization, and functional analysis of sortilin in tissues or cells via techniques like Western blot, immunohistochemistry, and flow cytometry. Researchers also use SORT1 antibodies to explore therapeutic strategies targeting sortilin-associated pathways, offering potential for treating neurodegenerative, cardiovascular, and metabolic disorders.
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