| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | TGMZ |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human TGM7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TGM7抗体的3篇参考文献的简要整理(注：TGM7研究较为有限，部分内容基于假设性文献结构，实际文献需通过学术数据库验证)：
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1. **文献名称**: *"Characterization of Transglutaminase 7 (TGM7) in Epidermal Differentiation"*
**作者**: Smith A, et al. (2018)
**摘要**: 本研究通过制备兔多克隆TGM7抗体，揭示了TGM7在皮肤表皮分化中的表达模式。抗体经Western blot和免疫荧光验证特异性，发现TGM7在角质形成细胞终末分化阶段上调，提示其参与细胞包膜交联过程。
2. **文献名称**: *"TGM7 Antibody Development and Its Application in Ovarian Cancer Biomarker Screening"*
**作者**: Chen L, et al. (2020)
**摘要**: 研究团队开发了一种高灵敏度的小鼠抗人TGM7单克隆抗体，用于检测卵巢癌组织中TGM7的异常表达。ELISA和免疫组化结果显示，TGM7在肿瘤微环境中的高表达与患者预后不良相关，提示其作为潜在生物标志物的价值。
3. **文献名称**: *"Role of TGM7 in Neural Development: Insights from Antibody-Mediated Functional Blockade"*
**作者**: Tanaka K, et al. (2016)
**摘要**: 利用TGM7中和抗体阻断其酶活性，研究发现TGM7在小鼠胚胎神经管闭合中起关键作用。抗体干预导致神经嵴细胞迁移异常，表明TGM7可能通过调节细胞外基质重塑影响发育过程。
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**注意**：上述文献为示例性内容，实际研究中TGM7可能因领域特异性存在不同命名或功能描述。建议通过PubMed或Google Scholar以关键词“TGM7 antibody”或“Transglutaminase 7”检索最新文献，并核实编号准确性(如是否为TGM2或TGM3的误写)。如需具体文献协助，可提供更多背景信息进一步筛选。
**Background of TGM7 Antibody**
Transglutaminase 7 (TG7), encoded by the *TGM7* gene, belongs to the transglutaminase enzyme family, which catalyzes protein crosslinking via ε-(γ-glutamyl)lysine bonds. While other transglutaminases (e.g., TG2 in celiac disease) are well-studied, TG7 remains less characterized. It is primarily expressed in epithelial tissues, including the skin and gastrointestinal tract, suggesting roles in barrier function and cellular differentiation.
TGM7 antibodies are tools used to investigate TG7's expression, localization, and function. Research indicates TG7 may contribute to keratinocyte differentiation in the skin and mucosal surfaces, but its precise biological and pathological roles are unclear. Some studies link TG7 autoantibodies to rare autoimmune conditions, such as dermatitis herpetiformis or neurological disorders, though evidence is preliminary.
Commercial TGM7 antibodies are typically developed in rabbits or mice, targeting specific epitopes (e.g., N-terminal regions). They are employed in techniques like Western blotting, immunohistochemistry, or ELISA to study TG7 in disease models or normal physiology. Challenges include ensuring antibody specificity due to structural homology among transglutaminases. Ongoing research aims to clarify TG7's involvement in tissue homeostasis, inflammation, and its potential as a diagnostic or therapeutic target.
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