| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | TN; TNA |
| WB Predicted band size | 23 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human CLEC3B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TRIP11抗体的模拟参考文献示例(请注意，以下文献信息为虚构，仅供格式参考)：
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1. **文献名称**: *TRIP11 regulates Golgi structure and microtubule organization in mammalian cells*
**作者**: Saito K, et al.
**摘要**: 本研究利用TRIP11特异性抗体，通过免疫荧光和Western blot分析，揭示了TRIP11蛋白在高尔基体结构和微管骨架动态调控中的关键作用，并发现其缺失导致细胞分泌功能异常。
2. **文献名称**: *TRIP11 expression correlates with tumor progression in colorectal cancer*
**作者**: Wu X, et al.
**摘要**: 通过免疫组化(IHC)结合TRIP11抗体，作者发现TRIP11在结直肠癌组织中高表达，且其水平与肿瘤转移和患者预后不良显著相关，提示其作为潜在生物标志物的价值。
3. **文献名称**: *TRIP11 antibody-based screening identifies novel interactors in vesicular trafficking*
**作者**: Bahl S, et al.
**摘要**: 本研究利用TRIP11抗体进行免疫共沉淀(Co-IP)和质谱分析，鉴定了多个与TRIP11相互作用的囊泡运输相关蛋白，为阐明其在细胞内运输中的分子机制提供了新线索。
4. **文献名称**: *Developmental regulation of TRIP11 in mouse embryonic fibroblasts*
**作者**: Zhang L, et al.
**摘要**: 通过TRIP11抗体检测小鼠胚胎成纤维细胞中的蛋白表达动态，研究发现TRIP11在胚胎发育早期阶段对细胞分化和凋亡具有重要调控作用。
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建议通过PubMed、Google Scholar等平台检索真实文献，关键词“TRIP11 antibody”或“TRIP11 Golgin”。如需具体文献协助，可提供更详细的研究方向或应用场景。
The TRIP11 (Thyroid Hormone Receptor Interactor 11) antibody is a tool used to study the TRIP11 protein, also known as Golgi-associated PDZ and Coiled-coil Motif Containing Protein (GOPC). TRIP11 is a multi-domain scaffold protein involved in intracellular trafficking, Golgi apparatus organization, and vesicle-mediated transport. It contains PDZ, coiled-coil, and proline-rich domains, enabling interactions with diverse partners, including receptors, kinases, and cytoskeletal components. TRIP11 plays critical roles in maintaining Golgi structure, regulating protein sorting, and facilitating cell adhesion/migration. Dysregulation of TRIP11 is linked to cancers (e.g., prostate, breast), skeletal disorders (e.g., spondyloepiphyseal dysplasia), and thyroid hormone signaling defects.
TRIP11 antibodies are widely used in research to detect protein expression, localization, and interactions via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Polyclonal antibodies often target specific domains (e.g., C-terminal region), while monoclonal versions offer higher specificity. Validation typically includes knockout (KO) cell lines or siRNA knockdown to confirm signal loss. These antibodies help explore TRIP11's role in diseases, such as its oncogenic potential via EGFR trafficking or its involvement in skeletal development through dysregulated collagen secretion. Commercial TRIP11 antibodies vary in host species, clonality, and conjugates, requiring careful selection based on experimental needs.
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