| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | GON-2; MLSN2; LTRPC3 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human TRPM3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TRPM3抗体的3篇参考文献示例(注：以下信息为模拟示例，实际文献需通过学术数据库查询确认)：
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1. **文献名称**：*TRPM3 is a nociceptor channel involved in the detection of noxious heat*
**作者**：Vriens J. et al.
**摘要**：该研究揭示了TRPM3离子通道作为伤害性热感受器的作用，通过特异性抗体阻断实验证实其在炎症性疼痛中的功能，为开发靶向TRPM3的镇痛策略提供依据。
2. **文献名称**：*Antibody-based targeting of TRPM3 suppresses pancreatic β-cell apoptosis in diabetes*
**作者**：Drews A. et al.
**摘要**：研究利用TRPM3特异性抗体抑制通道活性，发现其可减少高糖环境下胰岛β细胞凋亡，提示TRPM3可能成为糖尿病治疗的潜在靶点。
3. **文献名称**：*Development of a monoclonal antibody antagonist against TRPM3 for neuropathic pain management*
**作者**：Held K. et al.
**摘要**：报道了一种新型TRPM3单克隆抗体的开发，该抗体通过阻断通道钙离子内流显著缓解小鼠神经病理性疼痛，验证了其治疗应用潜力。
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**建议**：具体文献请通过PubMed、Google Scholar等平台以“TRPM3 antibody”“TRPM3 function”等关键词检索，并优先选择近五年内发表的高影响力期刊论文。
**Background of TRPM3 Antibodies**
TRPM3 (Transient Receptor Potential Melastatin 3) is a calcium-permeable ion channel belonging to the TRP superfamily, which plays critical roles in sensory transduction, thermosensation, and cellular calcium homeostasis. TRPM3 is expressed in various tissues, including the nervous system, pancreatic β-cells, and the retina. It is activated by heat, chemical ligands (e.g., pregnenolone sulfate), and mechanical stimuli, contributing to processes like insulin secretion, nociception, and detection of noxious heat.
TRPM3 antibodies are research tools designed to detect and study the expression, localization, and function of TRPM3 channels. These antibodies are crucial for immunohistochemistry, Western blotting, and flow cytometry, enabling investigations into TRPM3's physiological roles and its involvement in diseases. For instance, TRPM3 dysfunction has been linked to neuropathic pain, glaucoma, and metabolic disorders.
Recently, TRPM3 autoantibodies have gained attention in autoimmune and neurological contexts. In rare cases, autoantibodies targeting TRPM3 are associated with encephalitis and neuropathy, suggesting an autoimmune mechanism disrupting channel activity. Research on such antibodies aids in understanding autoimmune pathogenesis and developing diagnostic biomarkers or therapeutic strategies.
Overall, TRPM3 antibodies serve as vital reagents in both basic research and clinical applications, bridging molecular insights with disease mechanisms.
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