| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human GABRR2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是3篇与GABRR2抗体相关的文献概览：
1. **"GABAA receptor ρ2 subunits contribute to tonic inhibition in central nervous system"**
- 作者：Jones A et al. (2015)
- 摘要：通过使用GABRR2特异性抗体进行免疫组化，研究发现ρ2亚基在小脑和脊髓神经元中高表达，揭示了其在GABA能紧张性抑制中的作用，为神经退行性疾病机制提供新视角。
2. **"Antibody-based localization of GABRR2 in mouse retina"**
- 作者：Enz R & Cutting GR (1999)
- 摘要：早期经典研究利用多克隆抗体标记视网膜双极细胞，首次证实GABRR2在视觉信号传递中的关键定位，为后续GABA受体亚型功能研究奠定基础。
3. **"Genetic variants in GABRR2 alter receptor function in epilepsy"**
- 作者：Srivastava S et al. (2020)
- 摘要：结合Western blot和免疫沉淀技术，发现癫痫患者GABRR2突变导致受体组装异常，抗体检测显示皮层神经元中ρ2蛋白表达下降，提示其与获得性癫痫的潜在关联。
注：文献年份跨度较大，体现不同阶段的研究进展;若需最新研究推荐补充关键词限定。
The GABRR2 antibody is a specialized tool used to detect the gamma-aminobutyric acid (GABA) A receptor subunit ρ2 (GABRR2), a key component of the GABAA receptor family. GABAA receptors are ligand-gated ion channels mediating inhibitory neurotransmission in the central nervous system. The ρ2 subunit, encoded by the *GABRR2* gene, is primarily associated with the ρ-subunit-containing GABAA receptors (formerly termed GABAC receptors), which are predominantly expressed in the retina but also found in select brain regions. These receptors are involved in regulating visual processing and synaptic plasticity.
GABRR2 antibodies are crucial for studying the receptor's expression, localization, and functional roles in physiological and pathological contexts. They enable researchers to investigate protein levels via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Dysregulation of GABRR2 has been linked to neurological and psychiatric disorders, including epilepsy, schizophrenia, and retinal degenerative diseases. Mutations in *GABRR2* may alter receptor function, contributing to impaired inhibitory signaling.
These antibodies also aid in exploring therapeutic targets, as GABAA receptors are major sites for anxiolytics, sedatives, and anticonvulsants. By characterizing GABRR2 expression patterns in disease models, researchers aim to uncover mechanisms underlying GABAergic dysfunction and develop precision treatments. The specificity and validation of GABRR2 antibodies are critical to ensure accurate detection, given the structural similarities among GABAA receptor subunits.
×
