| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CG; CATG |
| WB Predicted band size | 29 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human CTSG |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CTSG抗体的3篇参考文献示例(文献信息为模拟内容，仅供参考)：
1. **文献名称**: *"Cathepsin G in Neutrophil-Mediated Inflammation: Mechanisms and Therapeutic Implications"*
**作者**: Korkmaz B, et al.
**摘要**: 探讨了CTSG在中性粒细胞介导的炎症反应中的作用，包括其蛋白酶活性对组织损伤的影响，并评估了特异性抗体在阻断CTSG活性以减轻炎症性疾病(如类风湿性关节炎)中的潜在治疗价值。
2. **文献名称**: *"Development of a High-Affinity Monoclonal Antibody for Human Cathepsin G Detection"*
**作者**: Smith J, et al.
**摘要**: 报道了一种新型单克隆抗体的开发与验证，该抗体能够特异性识别人类CTSG，适用于流式细胞术和免疫组化检测，为临床样本中CTSG表达水平的定量分析提供了可靠工具。
3. **文献名称**: *"Cathepsin G Promotes Atherosclerosis by Regulating Macrophage Polarization via TLR4 Signaling"*
**作者**: Li Y, et al.
**摘要**: 通过小鼠模型和体外实验，揭示了CTSG通过TLR4信号通路调控巨噬细胞极化并促进动脉粥样硬化斑块形成的机制，使用CTSG中和抗体可显著抑制该过程。
4. **文献名称**: *"The Role of Cathepsin G in Bacterial Clearance: Insights from Antibody-Based Inhibition Studies"*
**作者**: Pham CTN, et al.
**摘要**: 研究CTSG在宿主防御细菌感染中的双重作用，发现其抗体抑制实验可减少过度炎症反应，同时维持部分抗菌活性，提示靶向CTSG的抗体在脓毒症治疗中的潜在应用。
(注：以上文献为模拟示例，实际引用时请通过PubMed、Google Scholar等平台检索真实文献。)
**Background of CTSG Antibody**
Cathepsin G (CTSG) is a serine protease primarily secreted by activated neutrophils, playing critical roles in innate immunity, inflammation, and tissue remodeling. It is stored in azurophilic granules and released during neutrophil degranulation or NETosis. CTSG cleaves pathogens, regulates chemokine/cytokine activity, and processes extracellular matrix proteins. Dysregulated CTSG is implicated in chronic inflammatory diseases (e.g., rheumatoid arthritis, cystic fibrosis), vascular disorders (e.g., atherosclerosis), and cancer progression.
CTSG antibodies are essential tools for detecting CTSG expression, localization, and activity in research. They enable applications like immunohistochemistry, Western blotting, and flow cytometry, aiding studies on neutrophil function, protease-mediated signaling, and disease mechanisms. Therapeutic CTSG inhibitors are also explored to mitigate excessive proteolysis in pathologies. However, CTSG's dual role—both protective (antimicrobial) and harmful (tissue damage)—underscores the need for precise targeting. Antibodies with high specificity thus remain vital for dissecting CTSG's complex biology and translational potential.
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