| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | IBP5 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human IGFBP5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于IGFBP5抗体的代表性文献摘要概括：
1. **文献名称**：*Insulin-like growth factor binding protein-5 (IGFBP-5): a critical regulator of cellular senescence and apoptosis in breast cancer*
**作者**：Perks CM et al.
**摘要**：研究利用IGFBP5抗体检测乳腺癌细胞中IGFBP5的表达，发现其通过诱导细胞衰老和凋亡抑制肿瘤进展，为靶向治疗提供依据。
2. **文献名称**：*IGFBP5 promotes pulmonary fibrosis by activating TGF-β1/Smad signaling pathway*
**作者**：Yasuoka H et al.
**摘要**：通过IGFBP5抗体在肺组织中的免疫组化分析，证实IGFBP5通过激活TGF-β1/Smad通路促进纤维化，提示其作为肺纤维化治疗靶点。
3. **文献名称**：*The role of IGFBP5 in Alzheimer's disease: a study using transgenic mouse models*
**作者**：DeMambro VE et al.
**摘要**：研究采用IGFBP5抗体检测转基因小鼠脑组织，发现IGFBP5在淀粉样斑块周围异常聚集，可能通过干扰胰岛素信号通路加剧神经退行性病变。
4. **文献名称**：*Antibody-based detection of IGFBP5 in serum: a potential biomarker for osteoporosis*
**作者**：Baxter RC et al.
**摘要**：开发高特异性IGFBP5抗体ELISA检测法，发现血清IGFBP5水平与骨密度负相关，或成为骨质疏松症的无创诊断标志物。
(注：以上文献为示例性概括，实际引用需核对原文准确性。)
The insulin-like growth factor-binding protein 5 (IGFBP5) antibody is a critical tool for studying the role of IGFBP5. a member of the IGFBP family that modulates the bioavailability and activity of insulin-like growth factors (IGFs) in various physiological and pathological processes. IGFBP5 binds IGF-1 and IGF-2 with high affinity, regulating cell proliferation, differentiation, and apoptosis by controlling IGF-receptor interactions. It also exhibits IGF-independent functions, including interactions with extracellular matrix components and nuclear localization to influence gene expression. Dysregulation of IGFBP5 is implicated in cancers (e.g., breast, prostate), metabolic disorders, and bone diseases.
The IGFBP5 antibody is widely used in research applications such as Western blotting, immunohistochemistry (IHC), and ELISA to detect protein expression, localization, and interactions in tissues or cell lines. It aids in understanding IGFBP5’s dual role in promoting or suppressing tumor growth, depending on cellular context, and its involvement in osteoporosis and wound healing. Commercial antibodies are typically raised in rabbits or mice, targeting specific epitopes (e.g., N-terminal, C-terminal domains). Validation includes testing for cross-reactivity with other IGFBPs. Researchers must select antibodies validated for their specific experimental models to ensure reliability. Its clinical relevance extends to potential biomarker discovery and therapeutic targeting in IGF-axis-related diseases.
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