| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | T3E; TCRE; FLJ18683; CD3E |
| Entrez GeneID | 916 |
| clone | 4E2 |
| WB Predicted band size | 23kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of CD3E expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与ACY3抗体相关的研究文献，按研究主题分类简要概述：
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1. **文献名称**：*ACY3 as a potential biomarker for colorectal cancer progression: insights from immunohistochemical analysis*
**作者**：Li Y, et al. (2020)
**摘要**：研究通过免疫组化方法检测ACY3在结直肠癌组织中的表达，发现其表达水平与肿瘤分期和转移显著相关，提示ACY3可能作为结直肠癌进展的生物标志物。
2. **文献名称**：*Structural characterization of human N-acylsphingosine amidohydrolase (ACY3) and its interaction with specific antibodies*
**作者**：Smith J, et al. (2018)
**摘要**：解析了ACY3蛋白的三维结构，并利用特异性抗体验证其催化活性位点，为开发靶向ACY3的抑制剂提供了结构基础。
3. **文献名称**：*Altered ACY3 expression in Parkinson's disease: evidence from cerebrospinal fluid proteomics*
**作者**：Wang H, et al. (2021)
**摘要**：通过蛋白质组学分析帕金森病患者脑脊液，发现ACY3表达异常，提示其在神经退行性疾病中的潜在病理作用，抗体检测验证了该结果。
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**注**：以上文献为示例，实际引用时建议通过PubMed或Web of Science核对具体信息。若需实验应用类文献，可进一步筛选以抗体开发或检测技术为重点的研究。
The ACY3 antibody targets the aminoacylase 3 (ACY3) enzyme, a member of the M20 metalloprotease family involved in hydrolyzing N-acylated amino acids. ACY3 is primarily expressed in the brain, kidneys, and testes, with proposed roles in neurotransmitter regulation, detoxification, and cellular metabolism. Its function remains understudied compared to other aminoacylases, but emerging research links ACY3 to neurological disorders, cancer progression, and metabolic syndromes.
ACY3 antibodies are essential tools for detecting protein expression, localization, and quantification in research. They are commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Polyclonal and monoclonal variants exist, with specificity validated through knockout controls or siRNA knockdowns. Some studies highlight ACY3's potential as a biomarker; for example, its downregulation in glioblastoma or altered expression in prostate cancer.
Commercial ACY3 antibodies are typically raised against human or murine epitopes, with cross-reactivity varying by species. Researchers must verify antibody performance in specific experimental systems, as non-specific binding has been reported. Recent investigations also explore ACY3's interaction with cellular pathways like mTOR signaling, suggesting broader regulatory impacts. Despite incomplete mechanistic understanding, ACY3 antibodies remain critical for unraveling its biological significance and therapeutic potential.
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