| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | SDPII |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human PACSIN2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与PACSIN2抗体相关的文献概览(基于公开数据整理)：
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1. **文献名称**：*PACSIN2 regulates dynamics of platelet microtubules and is associated with thrombocytopenia*
**作者**：Bender M. et al. (2013)
**摘要**：研究利用PACSIN2特异性抗体探究其在小鼠血小板微管动态调节中的作用，发现PACSIN2缺失导致血小板减少症，揭示其通过调控微管稳定性影响血小板生成。
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2. **文献名称**：*PACSIN2 modulates EGFR activation and degradation in non-small cell lung cancer*
**作者**：Wang Y. et al. (2016)
**摘要**：通过免疫共沉淀(使用PACSIN2抗体)发现PACSIN2与EGFR存在相互作用，抑制PACSIN2表达可增强EGFR信号通路活性，提示其在肺癌中可能作为肿瘤抑制因子。
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3. **文献名称**：*Structural basis of F-BAR domain assembly in membrane deformation*
**作者**：Shimada A. et al. (2010)
**摘要**：利用PACSIN2抗体进行免疫荧光定位，结合冷冻电镜解析PACSIN2蛋白的F-BAR结构域如何介导细胞膜形变，阐明其在膜重塑中的分子机制。
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**提示**：若需获取全文或具体实验细节，建议通过PubMed或期刊官网检索标题/作者，结合DOI号定位文献。部分研究可能需关注抗体品牌(如Abcam、CST等厂商的产品应用)。
PACSIN2 (Protein kinase C and casein kinase substrate in neurons 2), also known as Syndapin-2. is a member of the PACSIN family of cytoplasmic adaptor proteins. It plays a critical role in regulating membrane dynamics, cytoskeletal organization, and intracellular trafficking. Structurally, PACSIN2 contains an N-terminal F-BAR domain that binds to curved membranes, a central SH3 domain mediating protein-protein interactions, and a C-terminal region involved in oligomerization. It interacts with key partners like dynamin, WASP, and N-WASP to facilitate vesicle formation, endocytosis, and actin remodeling.
PACSIN2 antibodies are essential tools for studying its expression, localization, and function in diverse biological contexts. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect PACSIN2 in tissues and cell lines. Research has linked PACSIN2 to neurological processes, cancer progression, and cardiovascular diseases. For example, it modulates synaptic vesicle recycling in neurons and influences cancer cell invasion by regulating matrix metalloproteinase trafficking. Polymorphisms in the PACSIN2 gene have also been associated with hypertension and kidney disease.
Antibody specificity is critical due to homology among PACSIN family members. Validation via knockout controls or siRNA knockdown is often recommended. Commercial PACSIN2 antibodies are typically raised against conserved epitopes, enabling cross-species reactivity. Ongoing studies continue to explore its roles in membrane trafficking disorders and potential therapeutic targeting.
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