Rabbit Polyclonal SH3GLB1 Antibody

SH3GLB1 antibody is a research tool designed to detect SH3 domain-containing GRB2-like protein B1 (SH3GLB1), also known as endophilin B1 or Bax-interacting factor 1. This protein plays critical roles in membrane trafficking, mitochondrial dynamics, and apoptosis regulation. SH3GLB1 belongs to the endophilin family, characterized by an N-terminal BAR domain that facilitates membrane curvature sensing and a C-terminal SH3 domain mediating protein-protein interactions. It localizes to mitochondrial and endosomal membranes, where it participates in autophagy (mitophagy), organelle morphology regulation, and vesicle formation. Studies link SH3GLB1 to pro-apoptotic pathways through interactions with Bax and Bcl-2 family proteins, as well as autophagy via associations with Beclin-1. Its dysfunction is implicated in cancer, neurodegenerative disorders, and metabolic diseases. The SH3GLB1 antibody is widely used in Western blotting, immunofluorescence, and immunohistochemistry to study protein expression, subcellular localization, and molecular mechanisms in disease models. Researchers also employ it to explore SH3GLB1's roles in cellular stress responses, mitochondrial quality control, and therapeutic target potential. Antibody specificity is typically validated using knockout controls, with common host species including rabbit and mouse. It demonstrates reactivity across human, mouse, and rat samples in most commercial versions.