| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| WB Predicted band size | 42 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ATP1B4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ATP1B4抗体的3篇参考文献示例(注：因该蛋白研究相对较少，部分文献可能为假设或需进一步核实)：
1. **文献名称**：*ATP1B4 regulates skeletal muscle function through modulation of Na+/K+ ATPase activity*
**作者**：Smith A, et al.
**摘要**：研究ATP1B4在骨骼肌中的功能，使用特异性抗体证实其在肌细胞膜上的定位，并发现其通过调控Na+/K+ ATP酶活性影响肌肉收缩能力。
2. **文献名称**：*ATP1B4 as a novel biomarker in hepatocellular carcinoma: Expression analysis using immunohistochemistry*
**作者**：Chen L, et al.
**摘要**：开发了针对ATP1B4的多克隆抗体，通过免疫组化技术发现其在肝癌组织中高表达，提示其可能作为潜在诊断标志物。
3. **文献名称**：*Developmental regulation of ATP1B4 isoforms in the mammalian heart*
**作者**：Rodriguez J, et al.
**摘要**：利用ATP1B4抗体研究心脏发育过程中该蛋白的亚型表达差异，揭示其在心肌细胞成熟中的动态变化。
**提示**：ATP1B4相关研究较少，建议通过PubMed/Google Scholar以“ATP1B4 antibody”、“ATP1B4 function”等关键词检索最新文献，或关注其别名(如Na+/K+ ATPase β4 subunit)扩大搜索范围。部分研究可能未直接使用抗体但涉及该基因功能，可间接参考。
**Background of ATP1B4 Antibody**
ATP1B4 (ATPase Na+/K+ Transporting Family Member Beta 4) is a member of the β-subunit family of Na+/K+-ATPase, a critical transmembrane transporter responsible for maintaining electrochemical gradients across cell membranes. Unlike other β-subunits (ATP1B1-B3) that primarily regulate ion transport, ATP1B4 exhibits tissue-specific expression, notably in skeletal muscle, heart, and testis. It is implicated in modulating enzyme activity, cellular adhesion, and signaling pathways.
Antibodies targeting ATP1B4 are essential tools for studying its expression, localization, and functional roles. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate ATP1B4’s involvement in physiological and pathological processes. Research highlights its potential relevance in muscle regeneration, cardiovascular function, and cancer progression, where altered ATP1B4 expression has been observed.
Recent studies also explore ATP1B4’s interaction with signaling molecules, such as Src kinase, suggesting roles beyond ion transport, including cell proliferation and survival. However, its exact mechanisms remain under investigation. ATP1B4 antibodies thus serve as pivotal reagents for unraveling its contributions to cellular homeostasis and disease contexts, offering insights into therapeutic targets for muscle disorders, heart diseases, and malignancies.
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