| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ROX; MDIG; MINA; NO52; JMJD10; MINA53 |
| WB Predicted band size | 53 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human RIOX2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于RIOX2抗体的3篇假设参考文献示例(注：RIOX2并非真实存在的蛋白名称，此处为虚构示例，供格式参考)：
1. **文献名称**: "RIOX2 Antibody Development for Detection of Oxidative Stress Markers in Cancer Cells"
**作者**: Zhang L, et al.
**摘要**: 本研究开发了一种高特异性RIOX2多克隆抗体，用于检测肿瘤细胞中RIOX2蛋白的表达水平。实验表明，RIOX2在结直肠癌细胞中显著上调，并与氧化应激通路激活相关。
2. **文献名称**: "Characterization of RIOX2 Function in Neuronal Differentiation Using CRISPR and Specific Antibodies"
**作者**: Patel S, et al.
**摘要**: 通过CRISPR技术敲除RIOX2基因，并利用特异性抗体验证蛋白表达缺失，发现RIOX2在小鼠神经元分化中调控线粒体活性氧(ROS)代谢。
3. **文献名称**: "RIOX2 Antibody-Based Immunohistochemical Analysis in Inflammatory Bowel Disease"
**作者**: Gomez-Rivera F, et al.
**摘要**: 采用RIOX2单克隆抗体对肠道组织样本进行免疫组化分析，揭示了RIOX2在炎症性肠病患者的肠上皮细胞中异常表达，提示其可能作为炎症调控的新靶点。
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**说明**：
- RIOX2为虚构名称，实际研究中请根据目标蛋白的正确名称(如RIOK2、NOX2等)检索文献。
- 若需真实文献，建议在PubMed或Web of Science中搜索具体蛋白或抗体名称。
RIOX2 (Ribosomal Oxygenase 2), also known as MINA or MYC-induced nuclear antigen, is a member of the JmjC domain-containing protein family. It was initially identified as a MYC-responsive gene involved in cell proliferation and differentiation. Structurally, RIOX2 contains a conserved JmjC domain, which is associated with hydroxylase or demethylase activity, though its precise enzymatic function remains under investigation. The protein localizes to the nucleolus and plays a role in ribosomal RNA (rRNA) processing and ribosome biogenesis, linking it to cellular growth and protein synthesis.
RIOX2 is implicated in epigenetic regulation, potentially influencing histone modification and chromatin remodeling. Studies suggest it may interact with MYC oncoproteins to modulate transcriptional programs critical for cell cycle progression and oncogenesis. Dysregulation of RIOX2 has been observed in various cancers, including neuroblastoma, glioblastoma, and breast cancer, where its overexpression correlates with poor prognosis and tumor aggressiveness.
RIOX2 antibodies are essential tools for investigating its biological roles, enabling detection via techniques like Western blotting, immunofluorescence, and immunohistochemistry. These antibodies help elucidate RIOX2's interaction networks, subcellular localization, and expression patterns in normal versus pathological states. Recent research also explores its potential as a therapeutic target or biomarker for cancer, emphasizing its importance in both basic and translational biomedical studies.
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