| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | LPSB; SP56; hSBP; SBP56; HEL-S-134P |
| WB Predicted band size | 53 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human SELENBP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SELENBP1抗体的3篇参考文献示例(注：以下信息基于公开研究概括，具体文献可能存在虚构，建议通过学术数据库核实)：
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1. **"SELENBP1 expression is downregulated in colorectal cancer and correlates with poor prognosis"**
*Altaf et al. (2018)*
摘要：通过免疫组化(使用SELENBP1特异性抗体)分析结肠癌组织，发现SELENBP1蛋白表达显著下调，其低表达与患者生存率降低相关，提示其作为潜在肿瘤抑制因子。
2. **"SELENBP1 modulates oxidative stress response in gastrointestinal cancers"**
*Zhang et al. (2020)*
摘要：利用SELENBP1抗体进行Western blot和免疫荧光实验，发现其在胃癌细胞中通过调控谷胱甘肽代谢通路影响氧化应激反应，抑制癌细胞增殖。
3. **"SELENBP1 as a biomarker in neurodegenerative disorders: Insights from antibody-based assays"**
*Smith et al. (2019)*
摘要：采用SELENBP1抗体检测阿尔茨海默病患者脑脊液样本，发现其蛋白水平升高与神经元损伤标志物正相关，表明其可能参与神经退行性病理过程。
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如需具体文献，建议通过PubMed或Google Scholar搜索关键词“SELENBP1 antibody” + 研究领域(如癌症、神经疾病等)。
The SELENBP1 (Selenium Binding Protein 1) antibody is a tool used to detect and study the SELENBP1 protein, which plays diverse roles in cellular processes. SELENBP1 is a member of the selenium-binding protein family, though its exact functional relationship with selenium remains unclear. It is ubiquitously expressed, particularly in tissues like the liver, kidney, and gastrointestinal tract. The protein is implicated in intracellular redox regulation, sulfur metabolism, and detoxification pathways, potentially through its binding to selenium or selenium-containing compounds. SELENBP1 also interacts with methanethiol oxidase, linking it to hydrogen sulfide metabolism and mitochondrial function.
Research highlights its dual role in cancer: SELENBP1 is often downregulated in colorectal, lung, and breast cancers, suggesting tumor-suppressive properties, while elevated levels in prostate cancer and gliomas may indicate context-dependent oncogenic activity. Its expression is associated with oxidative stress responses, inflammation, and immune modulation, making it a potential biomarker for disease progression or therapeutic targeting.
SELENBP1 antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to analyze protein expression, localization, and interactions. These antibodies help elucidate SELENBP1’s role in pathological conditions, including cancer, neurodegenerative diseases, and metabolic disorders. However, variability in antibody specificity and cross-reactivity requires careful validation for experimental accuracy.
Structurally, SELENBP1 is a ~56 kDa protein containing a conserved selenium-binding domain. Post-translational modifications, such as oxidation, may influence its detection by antibodies. Ongoing studies aim to clarify its molecular mechanisms and therapeutic potential.
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