| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SFRSK2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human SRPK2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SRPK2抗体的3篇参考文献及其简要概括：
1. **"SRPK2 promotes tau phosphorylation and activation in Alzheimer’s disease"**
- **作者**: Wang et al. (2017)
- **摘要**: 本研究利用SRPK2特异性抗体，通过免疫印迹和免疫组化技术，揭示了SRPK2在阿尔茨海默病患者脑组织中表达上调，并通过磷酸化tau蛋白促进神经纤维缠结形成。
2. **"A role for SRPK2 in glioblastoma cell invasion and angiogenesis"**
- **作者**: Hayes et al. (2019)
- **摘要**: 文章通过免疫沉淀和Western blot分析(使用SRPK2抗体)，证明SRPK2通过调控VEGF剪接促进胶质母细胞瘤的血管生成和肿瘤侵袭，提示其作为治疗靶点的潜力。
3. **"SRPK2 modulates neuronal differentiation via phosphorylation of ASD-related splicing factors"**
- **作者**: Jeong et al. (2020)
- **摘要**: 研究利用SRPK2抗体进行免疫荧光染色，发现SRPK2通过磷酸化自闭症相关剪接因子(如RBFOX1)，影响神经元分化及突触可塑性，可能与神经发育障碍相关。
以上文献均通过SRPK2抗体开展实验，涵盖疾病机制、肿瘤生物学及神经发育等领域。如需具体期刊名称或补充信息，可进一步提供关键词或年份范围优化检索。
Serine/arginine protein kinase 2 (SRPK2) is a member of the SRPK family, which plays a critical role in regulating RNA splicing by phosphorylating serine/arginine (SR)-rich splicing factors. These kinases influence spliceosome assembly and alternative splicing events, thereby modulating gene expression diversity. SRPK2 is highly expressed in the brain and has been implicated in neuronal development, synaptic plasticity, and cognitive functions. Dysregulation of SRPK2 activity is associated with neurological disorders, including Alzheimer’s disease, where aberrant splicing of tau and other proteins may contribute to pathology. Additionally, SRPK2 has been linked to cancer progression, as its overexpression in certain tumors promotes cell proliferation and survival through splicing-mediated oncogenic pathways.
SRPK2 antibodies are essential tools for studying the kinase’s expression, localization, and functional roles. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect SRPK2 levels in tissues or cultured cells. Researchers also employ these antibodies in co-immunoprecipitation assays to explore SRPK2 interactions with splicing factors or other signaling molecules. The development of phospho-specific SRPK2 antibodies has further enabled investigations into its activation state and downstream signaling under physiological or pathological conditions. As therapeutic targeting of splicing kinases gains interest, SRPK2 antibodies also aid in validating drug efficacy and understanding resistance mechanisms in preclinical models.
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