关键信息
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基因名
IGF2R
- 应用
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别名
(CI Man-6-P receptor)(CI-MPR)(M6PR)(300 kDa mannose 6-phosphate receptor)(MPR 300)(Insulin-like growth factor 2 receptor)(Insulin-like growth factor II receptor)(IGF-II receptor)(CD antigen CD222)
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种属
Bovine
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表达系统
HEK293
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P08169
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表达区间
628-772aa
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分子量
18.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
IGF2R (Insulin-like Growth Factor 2 Receptor) is a key component in the regulation of growth and development, primarily functioning to modulate the bioavailability of Insulin-like Growth Factor 2 (IGF2) and other ligands. Research has shown that IGF2R plays a critical role in various physiological processes, including cellular growth, differentiation, and apoptosis, making it a significant focus in cancer biology, metabolic disorders, and developmental diseases. The receptor functions through endocytosis, regulating the signaling pathways that influence cell proliferation and survival. Additionally, mutations or altered expression of IGF2R have been implicated in a range of malignancies, where loss of function may contribute to unregulated cell growth. The production of recombinant IGF2R proteins offers a valuable tool for studying its structure-function relationships, ligand interactions, and potential therapeutic applications. By utilizing recombinant DNA technology, researchers can generate large quantities of pure IGF2R proteins, enabling detailed biochemical assays and the development of targeted therapies. Furthermore, understanding the relationship between IGF2R and other signaling networks holds promise for uncovering novel approaches to cancer treatment and management of metabolic syndromes. The expanding body of research surrounding IGF2R positions it as a promising candidate for further exploration in both basic and translational sciences, with the potential to influence future strategies for disease intervention and management.
