Rabbit Polyclonal CCNE1 Antibody

The CCNE1 antibody is a crucial tool in biomedical research for detecting cyclin E1. a protein encoded by the *CCNE1* gene. Cyclin E1 plays a pivotal role in regulating the cell cycle, particularly during the G1-to-S phase transition, by forming active complexes with cyclin-dependent kinase 2 (CDK2). These complexes phosphorylate target proteins, such as retinoblastoma (Rb), to promote cell cycle progression. Dysregulation of CCNE1 is implicated in various cancers, including ovarian, breast, and endometrial cancers, where its overexpression correlates with tumor aggressiveness, poor prognosis, and resistance to therapies. The CCNE1 antibody is widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess protein expression levels, subcellular localization, and potential post-translational modifications. Researchers also employ it to study mechanisms underlying genomic instability, oncogenesis, and therapeutic resistance. Specificity and validation of CCNE1 antibodies are critical, as isoforms or truncated variants may exist. Recent studies explore CCNE1 as a biomarker for patient stratification and as a therapeutic target, particularly in combination with CDK inhibitors. Its utility extends to preclinical models, aiding in mechanistic studies and drug development.