| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | LAMP; CD208; DCLAMP; LAMP-3; TSC403; DC LAMP; DC-LAMP |
| WB Predicted band size | 44 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human LAMP3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是3篇关于LAMP3抗体的相关文献摘要信息：
1. **文献名称**: LAMP3 regulates autophagy and apoptosis in hepatocellular carcinoma
**作者**: Fujiwara Y et al.
**摘要**: 研究发现LAMP3在肝癌细胞中高表达，使用特异性抗体验证其通过调控溶酶体功能促进自噬抵抗化疗药物诱导的凋亡，提示其作为潜在治疗靶点。
2. **文献名称**: LAMP3 expression in dendritic cells drives antitumor immunity
**作者**: Kato M et al.
**摘要**: 通过免疫组化(使用兔源LAMP3单抗)证实树突状细胞中LAMP3高表达与T细胞活化正相关，机制研究表明LAMP3通过MHC-II抗原递送增强肿瘤免疫应答。
3. **文献名称**: LAMP3 as a predictive biomarker for cervical cancer lymph node metastasis
**作者**: Li X et al.
**摘要**: 利用抗LAMP3抗体对宫颈癌组织进行免疫染色，发现其表达水平与淋巴结转移显著相关，多变量分析显示LAMP3可作为独立预后标志物。
注：以上为模拟文献，实际文献需通过PubMed等数据库检索(如PMID: 32581335等真实研究)。建议使用关键词"LAMP3 antibody"+"cancer/immune"查阅最新论文。
**Background of LAMP3 Antibody**
The **LAMP3 antibody** is a research tool targeting Lysosome-Associated Membrane Protein 3 (LAMP3), a transmembrane glycoprotein belonging to the LAMP family. LAMP3. also known as DC-LAMP or CD208. is predominantly expressed in specialized immune cells, particularly mature dendritic cells (DCs), where it localizes to lysosomal and endosomal membranes. Structurally, it features a heavily glycosylated luminal N-terminal domain and a short cytoplasmic tail, which facilitate its role in lysosomal stability, antigen processing, and cellular trafficking.
LAMP3 is a marker of DC maturation, upregulated during activation, and implicated in adaptive immunity by supporting antigen presentation to T-cells. Beyond immunology, LAMP3 has gained attention in oncology due to its overexpression in various cancers, including lung, breast, and cervical carcinomas. Studies link its expression to tumor progression, metastasis, and therapy resistance, possibly through mechanisms involving hypoxia, endoplasmic reticulum stress, or immunosuppressive microenvironments.
The LAMP3 antibody is widely used in techniques like immunohistochemistry, flow cytometry, and Western blotting to study DC biology, tumor immunology, and cancer biomarkers. It also holds potential in diagnostic and therapeutic research, such as evaluating LAMP3 as a prognostic indicator or a target for drug delivery. However, its functional diversity across cell types and diseases warrants further investigation to clarify its precise roles and therapeutic relevance.
×
