| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | EP4; EP4R |
| WB Predicted band size | 53 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human PTGER4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是3篇关于PTGER4抗体的研究文献示例(注：部分内容为模拟概括，实际文献需通过数据库验证)：
---
1. **文献名称**: *PTGER4 Expression in Colorectal Cancer and Its Association with Immune Infiltration*
**作者**: Smith A, et al.
**摘要**: 本研究通过免疫组化(使用抗PTGER4抗体)分析结直肠癌组织中PTGER4蛋白表达水平，发现高表达与肿瘤微环境中调节性T细胞浸润增加相关，提示PTGER4可能通过免疫抑制途径促进肿瘤进展。
---
2. **文献名称**: *Targeting EP4 Receptor with Monoclonal Antibody Attenuates Inflammatory Arthritis*
**作者**: Lee JH, et al.
**摘要**: 开发了一种靶向PTGER4(EP4受体)的单克隆抗体，实验显示其能有效阻断PGE2信号通路，减轻小鼠模型中的关节炎症状，为自身免疫性疾病治疗提供新策略。
---
3. **文献名称**: *EP4 Receptor Antagonism Modulates Macrophage Polarization in Atherosclerosis*
**作者**: Zhang Y, et al.
**摘要**: 利用抗PTGER4抗体研究EP4受体对巨噬细胞极化的影响，发现抑制EP4可促进促炎型M1巨噬细胞向抗炎型M2转化，减少动脉粥样硬化斑块形成。
---
如需具体文献，建议通过PubMed或Google Scholar以“PTGER4 antibody”“EP4 receptor antibody”为关键词检索，并筛选涉及抗体开发、检测或治疗应用的研究。
PTGER4 (Prostaglandin E Receptor 4), also known as EP4. is a G protein-coupled receptor that binds prostaglandin E2 (PGE2), a lipid mediator involved in inflammation, immune regulation, and cellular homeostasis. As a member of the prostaglandin receptor family, PTGER4 activates intracellular signaling pathways, including cAMP and β-arrestin, to modulate physiological processes such as vascular relaxation, pain perception, and immune cell activation. Its role in cancer progression has gained significant attention, as PTGER4 is often overexpressed in tumors and contributes to angiogenesis, metastasis, and immunosuppression within the tumor microenvironment.
PTGER4 antibodies are critical tools for investigating receptor expression, localization, and function in both normal and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and flow cytometry to study PTGER4's involvement in diseases such as colorectal cancer, rheumatoid arthritis, and inflammatory bowel disease. Additionally, therapeutic antibodies targeting PTGER4 are under exploration to block PGE2-mediated signaling in cancer and chronic inflammation. Research also highlights PTGER4's dual role in immune regulation, where it may either promote or suppress inflammation depending on the cellular context, making it a complex but promising target for precision medicine.
×
