Rabbit Polyclonal PKD1 Antibody

The PKD1 antibody is a critical tool in studying autosomal dominant polycystic kidney disease (ADPKD), a common genetic disorder caused by mutations in the *PKD1* gene. Located on chromosome 16. *PKD1* encodes polycystin-1. a large transmembrane protein involved in cell-cell interactions, mechanosensation, and signaling pathways regulating renal tubular integrity. Over 80% of ADPKD cases are linked to *PKD1* mutations, leading to cyst formation, kidney enlargement, and progressive renal failure. PKD1 antibodies are designed to detect polycystin-1. aiding in research on its expression, localization, and functional roles. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein levels in tissues or cell models. Due to polycystin-1’s complex structure—featuring a large extracellular N-terminal domain and multiple transmembrane segments—antibody validation is essential to ensure specificity, particularly given homology with other proteins like polycystin-2 (encoded by *PKD2*). Researchers also employ PKD1 antibodies to investigate disease mechanisms, such as dysregulated cell proliferation, apoptosis, and cyst fluid secretion. Their applications extend to evaluating therapeutic interventions targeting polycystin-1 pathways. However, challenges persist, including the protein’s low endogenous expression and technical limitations in detecting certain pathogenic variants. Ongoing advancements aim to refine antibody sensitivity and specificity, supporting both basic research and potential clinical diagnostics.