Rabbit Polyclonal BCL3 Antibody

The BCL3 (B-cell lymphoma 3) antibody is a critical tool for studying the BCL3 protein, a member of the IκB family that regulates NF-κB signaling. BCL3 functions as a transcriptional co-regulator, modulating cell proliferation, survival, and immune-inflammatory responses. Unlike other IκB proteins, BCL3 can either enhance or suppress NF-κB activity depending on cellular context, contributing to its dual role in cancer progression and suppression. It is frequently implicated in hematologic malignancies (e.g., B-cell lymphomas, leukemia) and solid tumors, where dysregulated expression correlates with poor prognosis, therapy resistance, or metastasis. BCL3 antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect protein expression levels, subcellular localization, and interactions with partners like p50/p52 NF-κB subunits. Research also employs these antibodies in chromatin immunoprecipitation (ChIP) to map BCL3-binding genomic regions, revealing its role in gene regulation. Structurally, BCL3 contains ankyrin repeat domains critical for protein-protein interactions. Its complex regulation—via phosphorylation, ubiquitination, and proteasomal degradation—makes it a focus for therapeutic targeting. BCL3 antibodies thus serve as essential reagents in both basic research and clinical studies exploring cancer mechanisms, biomarker discovery, and potential NF-κB pathway-based therapies.