| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | TKT; MIG20a; NTRKR3; TYRO10 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human DDR2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DDR2抗体的虚构参考文献示例(内容为模拟创作，非真实文献)：
1. **文献名称**：*DDR2-Specific Antibody Inhibits Collagen-Induced Tumor Cell Invasion in Breast Cancer Models*
**作者**：Smith, J.R. et al.
**摘要**：研究证明，靶向DDR2(盘状结构域受体酪氨酸激酶2)的单克隆抗体可阻断胶原蛋白激活的DDR2信号通路，显著抑制乳腺癌细胞迁移和侵袭，提示其在抑制肿瘤转移中的潜在价值。
2. **文献名称**：*Therapeutic Targeting of DDR2 with Neutralizing Antibodies Attenuates Liver Fibrosis in Mice*
**作者**：Wang, L. & Gonzalez, S.
**摘要**：通过构建肝纤维化小鼠模型，发现使用DDR2中和抗体可减少成纤维细胞活化及细胞外基质沉积，表明靶向DDR2的抗体疗法可能成为抗纤维化治疗的新策略。
3. **文献名称**：*Development of a High-Affinity Anti-DDR2 Antibody for Functional and Diagnostic Applications*
**作者**：Kim, H. et al.
**摘要**：报道了一种新型高亲和力DDR2抗体的开发，该抗体通过噬菌体展示技术筛选，可特异性识别DDR2胞外域并抑制其激酶活性，适用于体外检测和功能研究。
4. **文献名称**：*DDR2/STAT3 Crosstalk in Osteosarcoma Progression and Antibody-Based Intervention*
**作者**：Chen, X. et al.
**摘要**：揭示DDR2与STAT3通路在骨肉瘤中的交互作用，使用DDR2抗体阻断后可下调STAT3磷酸化，抑制肿瘤生长，为靶向联合治疗提供依据。
(注：以上文献及摘要均为示例性虚构，实际研究需查阅真实数据库如PubMed。)
**Background of DDR2 Antibodies**
DDR2 (Discoidin Domain Receptor 2) is a transmembrane tyrosine kinase receptor that binds collagen to regulate cell adhesion, proliferation, and extracellular matrix remodeling. It plays critical roles in development, tissue homeostasis, and pathological processes such as fibrosis, cancer, and osteoarthritis. DDR2 antibodies are immunological tools designed to detect, quantify, or inhibit DDR2 in experimental and clinical settings.
These antibodies are essential for studying DDR2’s signaling mechanisms, including its activation by collagen ligands and downstream pathways (e.g., MAPK, PI3K/AKT). In cancer research, DDR2 antibodies help investigate its dual role as both a tumor suppressor and promoter, depending on context. Overexpression or mutations in DDR2 are linked to tumor progression, metastasis, and therapy resistance, making it a potential therapeutic target.
DDR2 antibodies are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry to assess protein expression in tissues or cell lines. Some therapeutic antibodies are also being explored to block aberrant DDR2 signaling in diseases. Challenges include ensuring specificity due to structural similarities with DDR1. a related receptor. Validated DDR2 antibodies are critical for advancing research in fibrosis, cancer biology, and regenerative medicine, offering insights into targeted therapies and diagnostic biomarkers.
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