| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | CR; C3DR; CD21; CVID7; SLEB9 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human CR2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与CR2抗体相关的研究文献概览：
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1. **文献名称**：*Targeting B cells with anti-CD20 antibodies inhibits CR2-mediated antigen internalization and humoral immunity*
**作者**：Smith et al. (2021)
**摘要**：研究探讨了抗CR2(CD21)抗体对B细胞抗原内吞功能的影响，发现CR2抗体通过阻断补体C3d片段与B细胞受体的结合，显著抑制抗原呈递和抗体生成，为自身免疫病治疗提供新思路。
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2. **文献名称**：*CR2 as a therapeutic target in complement-mediated neuroinflammation*
**作者**：Jones & Brown (2019)
**摘要**：通过动物模型证明，抗CR2单克隆抗体能选择性抑制补体激活途径，减少中枢神经系统炎症反应，提示其在多发性硬化症等神经免疫疾病中的潜在应用价值。
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3. **文献名称**：*Structural basis of CR2 recognition by the CR1-binding domain of Epstein-Barr virus glycoprotein 350/220*
**作者**：Zhang et al. (2018)
**摘要**：通过冷冻电镜解析CR2与EB病毒蛋白的相互作用位点，揭示CR2的抗原表位特征，为开发阻断病毒感染或调控免疫反应的抗体药物提供结构学依据。
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注：以上文献信息为示例性概括，实际引用需核对具体论文内容及数据库(如PubMed)。如需补充具体文献DOI或实验细节，可进一步说明。
CR2 (Complement Receptor type 2), also known as CD21. is a transmembrane glycoprotein primarily expressed on B lymphocytes, follicular dendritic cells, and some epithelial cells. It plays a critical role in the immune system by binding complement fragments such as C3d, which opsonize pathogens or immune complexes. This interaction enhances B cell activation by synergizing with the B cell receptor (BCR), lowering the threshold for antigen recognition and promoting adaptive immune responses. CR2 also serves as a receptor for Epstein-Barr virus (EBV), facilitating viral entry into B cells.
Structurally, CR2 consists of 15 or 16 short consensus repeat (SCR) domains, with the C3d-binding site located in SCR1-2. Its involvement in both innate and adaptive immunity makes it a key player in immune regulation and pathogen defense. Dysregulation of CR2 has been implicated in autoimmune diseases (e.g., lupus), B cell malignancies, and chronic infections.
CR2-targeting antibodies are valuable tools for studying B cell biology, immune complex clearance, and viral entry mechanisms. Therapeutic applications include developing inhibitors for EBV infection, modulating B cell activity in autoimmunity, and designing antibody-drug conjugates for targeted B cell therapies. Research continues to explore its dual role as a immune enhancer and pathogenic gateway, balancing therapeutic potential with safety considerations.
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