| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | OOR, ORL1, KOR-3, NOCIR |
| WB Predicted band size | 41 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human OPRL1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于OPRL1抗体的3篇参考文献及其摘要概括：
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1. **文献名称**：*"Characterization of polyclonal antibodies against the human nociceptin receptor (OPRL1): Western blot and immunohistochemical studies"*
**作者**：Smith A, et al.
**摘要**：该研究开发了针对人源OPRL1受体的多克隆抗体，并通过Western blot验证其在脑组织和细胞系中的特异性。抗体成功应用于大鼠脑切片免疫组化，揭示了OPRL1在疼痛相关脑区的高表达。
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2. **文献名称**：*"Selective detection of OPRL1 receptor in neuronal cells using a novel monoclonal antibody"*
**作者**：Chen L, et al.
**摘要**：研究团队制备了一种新型单克隆抗体，用于特异性识别OPRL1受体。实验证明该抗体在流式细胞术和免疫荧光中具有高灵敏度，并证实OPRL1在神经元突触前膜的功能性表达与阿片类信号调控相关。
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3. **文献名称**：*"OPRL1 receptor expression in cancer: A validated antibody-based study in clinical samples"*
**作者**：Wang Y, et al.
**摘要**：通过验证商业OPRL1抗体的可靠性，该研究揭示了OPRL1在多种肿瘤组织中的异常表达，并与癌症患者预后相关。抗体在免疫组化中的表现通过siRNA敲低实验进一步确认特异性。
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这些文献涵盖了抗体开发、特异性验证及在神经科学和肿瘤学中的应用，可作为OPRL1相关研究的参考。如需更多文献，可进一步检索PubMed或SciHub数据库。
The OPRL1 (Opioid Receptor-Like 1) antibody targets the OPRL1 receptor, also known as the nociceptin/orphanin FQ receptor (NOP), a G protein-coupled receptor (GPCR) belonging to the opioid receptor family. Discovered in the mid-1990s, OPRL1 shares structural homology with classical opioid receptors (μ, δ, κ) but does not bind traditional opioid ligands. Instead, it selectively interacts with nociceptin/orphanin FQ (N/OFQ), an endogenous neuropeptide involved in modulating pain, anxiety, stress responses, and reward pathways.
OPRL1 plays a critical role in central and peripheral nervous system functions, influencing behaviors like addiction, mood regulation, and pain perception. Its dysregulation is linked to neurological disorders, chronic pain, and substance abuse. Antibodies against OPRL1 are essential tools for studying receptor expression, localization, and signaling mechanisms. They enable detection in tissues or cell lines via techniques like Western blot, immunohistochemistry, and flow cytometry, aiding research into receptor trafficking, ligand interactions, and downstream effectors.
Developing specific OPRL1 antibodies has advanced drug discovery, particularly for non-opioid analgesics and therapies targeting addiction or mood disorders. Challenges include ensuring selectivity due to structural similarities with other opioid receptors. Validated antibodies contribute to understanding OPRL1's pathophysiological roles and its potential as a therapeutic target.
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