Rabbit Polyclonal LRP8 Antibody

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P11466(LRP8 Antibody) at dilution 1/20. (Original magnification: ×200)    

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P11466(LRP8 Antibody) at dilution 1/20. (Original magnification: ×200)    

The LRP8 antibody targets the low-density lipoprotein receptor-related protein 8 (LRP8), also known as apolipoprotein E receptor 2 (ApoER2), a cell surface receptor belonging to the LDL receptor family. LRP8 plays critical roles in lipid metabolism, cellular signaling, and neurodevelopment. It is highly expressed in the brain, particularly in neurons, and interacts with ligands like Reelin, a glycoprotein essential for neuronal migration, synaptic plasticity, and cognitive functions. LRP8 also participates in the regulation of tau phosphorylation and β-amyloid metabolism, implicating it in Alzheimer’s disease pathology.

Antibodies against LRP8 are vital tools for studying its expression, localization, and function in physiological and pathological contexts. They are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to investigate LRP8’s role in neurodevelopmental disorders, neurodegenerative diseases, and reproductive biology (e.g., LRP8 mutations are linked to infertility). Additionally, these antibodies aid in exploring LRP8-mediated signaling pathways, including the Dab1-dependent Reelin pathway, which influences neuronal positioning and brain development.

Researchers prioritize antibodies with high specificity and affinity to ensure accurate detection, given LRP8’s structural complexity and homology with other LDL receptors. Commercial LRP8 antibodies are typically validated in model organisms like mice and rats, supporting translational research across neuroscience and metabolic studies.