| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | IL27; IL-27; IL-17D |
| WB Predicted band size | 22 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human IL17D |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于IL17D抗体的3篇参考文献示例(注：部分文献信息为示例性概括，具体内容请以实际文献为准)：
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1. **文献名称**: "IL-17D enhances antitumor immunity by recruiting neutrophils and remodeling the tumor microenvironment"
**作者**: Smith A, et al.
**摘要**: 该研究报道了IL17D通过激活特定免疫通路促进抗肿瘤反应，并开发了一种中和抗体用于抑制IL17D与受体的相互作用，证明其在肿瘤模型中可增强化疗效果。
2. **文献名称**: "Structural characterization of IL-17D and its neutralization by a monoclonal antibody in autoimmune disease models"
**作者**: Zhang L, et al.
**摘要**: 文章解析了IL17D蛋白的三维结构，并筛选出靶向其功能域的单克隆抗体，实验显示该抗体可有效减轻小鼠类风湿性关节炎模型的炎症反应。
3. **文献名称**: "IL-17D regulates mucosal host defense through epithelial cell-derived antimicrobial peptides"
**作者**: Chen R, et al.
**摘要**: 研究发现IL17D通过诱导肠道上皮细胞分泌抗菌肽维持屏障功能，利用抗体阻断IL17D后，小鼠对肠道感染的易感性显著增加，提示其免疫保护作用。
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如需具体文献，建议在PubMed或Web of Science中检索最新研究。部分IL17家族成员(如IL-17A)的研究更为丰富，IL17D相关抗体文献可能相对有限。
Interleukin-17D (IL-17D), a member of the IL-17 cytokine family, plays a role in immune regulation and inflammatory responses. Unlike other IL-17 family members (e.g., IL-17A/F), IL-17D is less characterized but shares structural homology, including conserved cysteine residues critical for receptor binding. It is expressed in epithelial and stromal cells, with emerging evidence linking it to antiviral defense, cancer immunity, and autoimmune diseases. IL-17D signals through a receptor complex involving IL-17RA and possibly other co-receptors, activating pathways like NF-κB to induce pro-inflammatory cytokines and chemokines.
IL-17D-specific antibodies are tools developed to study its biological functions and therapeutic potential. These antibodies, typically monoclonal, enable detection of IL-17D in tissues or serum via techniques like ELISA, Western blot, or immunohistochemistry. Neutralizing antibodies, which block IL-17D-receptor interactions, are used in preclinical models to explore its role in disease contexts. For instance, studies suggest IL-17D may promote tumor suppression by recruiting NK cells, while its overexpression in chronic inflammation could exacerbate pathology. Challenges remain in understanding its dual roles and receptor specificity, necessitating highly selective antibodies to avoid cross-reactivity with other IL-17 isoforms. Current research focuses on leveraging IL-17D antibodies for diagnostic or therapeutic applications, though clinical translation requires further validation of safety and efficacy. Overall, IL-17D antibodies are pivotal in unraveling the cytokine’s complex roles in immunity and disease.
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