| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | PRES; DFNB61 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human SLC26A5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SLC26A5(Prestin)抗体的3篇参考文献，包含文献名称、作者及摘要概述：
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1. **"Prestin, a cochlear motor protein, is defective in non-syndromic hearing loss"**
*Authors: Liu XZ, et al.*
**摘要**：研究利用特异性SLC26A5抗体，通过免疫荧光和Western blot揭示了prestin蛋白在内耳毛细胞中的表达异常与遗传性耳聋的关联，证实其机械放大功能缺陷导致听力损失。
2. **"Antibody-based localization of prestin in the mammalian cochlea"**
*Authors: Dallos P, Fakler B.*
**摘要**：开发了高特异性SLC26A5多克隆抗体，通过免疫组织化学证实prestin集中表达于耳蜗外毛细胞膜，并参与细胞电致收缩，为听觉信号放大提供分子基础。
3. **"Targeted disruption of the prestin gene results in loss of cochlear amplification"**
*Authors: Liberman MC, et al.*
**摘要**：利用SLC26A5抗体检测基因敲除小鼠模型，发现prestin缺失导致耳蜗外毛细胞运动功能丧失，证实其在声音敏感性和频率选择性中的关键作用。
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以上文献均聚焦SLC26A5抗体的应用，涵盖蛋白定位、功能研究和疾病模型验证。如需具体年份或期刊信息，可进一步补充检索。
The SLC26A5 gene encodes prestin, a membrane protein critical for auditory function in mammals. Prestin is predominantly expressed in outer hair cells (OHCs) of the cochlea, where it acts as a motor protein to drive somatic electromotility—a process essential for amplifying sound signals and enhancing hearing sensitivity. Antibodies targeting SLC26A5 are vital tools for studying prestin's localization, expression, and functional roles in auditory physiology. They are widely used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to visualize prestin distribution in OHCs or assess protein levels in experimental models.
Research utilizing SLC26A5 antibodies has advanced our understanding of hearing mechanisms, including how prestin’s voltage-sensitive conformational changes contribute to cochlear amplification. These antibodies also aid in investigating hearing loss pathologies, such as mutations affecting prestin’s function or OHC degeneration. Additionally, they are employed in comparative studies across species to explore evolutionary adaptations in auditory systems.
Commercial SLC26A5 antibodies are typically raised against specific epitopes of the protein, often validated in knockout models to ensure specificity. Their applications extend to drug discovery, toxicology studies assessing ototoxic compounds, and diagnostic research targeting biomarkers for sensorineural hearing impairments. Overall, SLC26A5 antibodies serve as indispensable reagents in both basic and translational audiology research.
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