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Rabbit Polyclonal KCNA3 Antibody

  • 中文名: KCNA3抗体
  • 别    名: MK3; HGK5; HLK3; PCN3; HPCN3; KV1.3; HUKIII
货号: IPDX12768
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesMK3; HGK5; HLK3; PCN3; HPCN3; KV1.3; HUKIII
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human KCNA3
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于KCNA3(Kv1.3通道)抗体的3篇参考文献,涵盖其在免疫调节和疾病中的研究:

1. **文献名称**:*Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases*

**作者**:Beeton, C., et al.

**摘要**:研究通过特异性抗体或肽类抑制剂靶向Kv1.3通道(KCNA3编码),发现其可选择性抑制效应记忆T细胞活性,为多发性硬化等自身免疫病提供治疗策略。

2. **文献名称**:*Potassium channels as targets for specific immunomodulation*

**作者**:Chandy, K.G., et al.

**摘要**:综述KCNA3编码的Kv1.3通道在T细胞和巨噬细胞中的功能,探讨其抗体或抑制剂通过调节钙信号通路影响免疫反应,可能用于炎症性疾病治疗。

3. **文献名称**:*Autoantibodies to potassium channels in patients with limbic encephalitis*

**作者**:Kleopa, K.A., et al.

**摘要**:报道边缘性脑炎患者体内存在针对KCNA3等钾通道的自身抗体,提示这些抗体可能通过干扰神经元电活动导致认知障碍和癫痫发作。

4. **文献名称**:*The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight*

**作者**:Xu, J., et al.

**摘要**:利用KCNA3抗体阻断Kv1.3通道活性,发现其影响脂肪代谢和能量平衡,提示该通道在肥胖相关代谢疾病中的潜在作用。

以上研究涉及KCNA3抗体在免疫调控、神经疾病及代谢中的机制探索。

背景信息

KCNA3 antibodies target the Kv1.3 voltage-gated potassium channel, encoded by the *KCNA3* gene. This channel plays a critical role in regulating membrane potential and cellular excitability, particularly in immune cells (e.g., T and B lymphocytes) and neurons. Kv1.3 facilitates potassium efflux during lymphocyte activation, influencing calcium signaling and cytokine production. Dysregulation of Kv1.3 is linked to autoimmune diseases (e.g., multiple sclerosis, rheumatoid arthritis), neuroinflammatory disorders, and certain cancers. Antibodies against KCNA3 are essential research tools for studying channel expression, localization, and function. They are used in techniques like Western blotting, immunohistochemistry, and flow cytometry to explore Kv1.3's role in immune responses or neurological pathways. Therapeutic interest in Kv1.3 inhibitors, including monoclonal antibodies, has grown due to their potential to suppress overactive immune cells without broad immunosuppression. However, KCNA3 antibodies may also arise pathologically in autoimmune contexts, contributing to channel dysfunction. Research continues to clarify their diagnostic and therapeutic utility, balancing the need for targeted immunomodulation against risks of off-target effects.

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