| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Alpha-(1,6)-fucosyltransferase, Alpha1-6FucT, Fucosyltransferase 8, GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase, GDP-fucose--glycoprotein fucosyltransferase, Glycoprotein 6-alpha-L-fucosyltransferase, FUT8 |
| Entrez GeneID | 2530 |
| WB Predicted band size | 66.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This FUT8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 329-357 amino acids from the Central region of human FUT8. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于FUT8抗体的3篇示例参考文献(注：以下内容为概括性示例，实际文献需通过学术数据库查询)：
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1. **文献名称**：*FUT8 knockout in CHO cells enhances antibody-dependent cellular cytotoxicity by reducing core fucosylation*
**作者**：Ihara, Y., et al.
**摘要**：该研究通过敲除CHO细胞中的FUT8基因，证明抗体核心岩藻糖基化水平显著降低，导致抗体依赖性细胞毒性(ADCC)增强，为抗体药物优化提供了新策略。
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2. **文献名称**：*Role of FUT8 in regulating IgG1 N-linked glycosylation and therapeutic antibody efficacy*
**作者**：Shinkawa, T., et al.
**摘要**：文章分析了FUT8介导的核心岩藻糖基化对抗体Fc段与免疫细胞表面受体结合的影响，发现抑制FUT8可提高单克隆抗体在肿瘤治疗中的临床效果。
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3. **文献名称**：*FUT8 overexpression correlates with poor prognosis in colorectal cancer and modulates tumor immunity*
**作者**：Wang, H., et al.
**摘要**：研究通过FUT8抗体检测发现，FUT8在结直肠癌中高表达，其通过调控T细胞活化和免疫检查点分子，促进肿瘤免疫逃逸，提示其作为治疗靶点的潜力。
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如需具体文献，建议在PubMed或Web of Science中搜索关键词“FUT8 antibody”、“core fucosylation”或“therapeutic antibodies”。
**Background of FUT8 Antibody**
FUT8 (α-1.6-fucosyltransferase) is a key enzyme responsible for catalyzing the transfer of fucose to the innermost GlcNAc residue of N-glycans via an α-1.6 linkage, a process termed core fucosylation. This post-translational modification critically regulates the biological functions of numerous membrane-bound and secreted proteins, including growth factor receptors, immunoglobulins, and adhesion molecules. Dysregulation of FUT8 activity has been implicated in various pathologies, such as cancer metastasis, chronic inflammation, and immune disorders, highlighting its significance in cellular signaling and disease progression.
FUT8 antibodies are essential tools for detecting and quantifying FUT8 expression and localization in tissues or cells. They are widely utilized in research to investigate the role of core fucosylation in protein stability, receptor activation, and cell-cell interactions. For instance, studies using FUT8 antibodies have revealed its involvement in modulating EGFR signaling in tumors and regulating antibody-dependent cellular cytotoxicity (ADCC) in therapeutic monoclonal antibodies.
Developed through immunization with peptide antigens or recombinant FUT8 proteins, these antibodies are validated for applications like Western blotting, immunohistochemistry, and flow cytometry. Their specificity and sensitivity make them valuable for both basic research and potential diagnostic or therapeutic exploration in diseases linked to aberrant glycosylation.
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