| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CEA; CGM1; W264; W282; CD66D |
| Entrez GeneID | 1084 |
| clone | 8D5F12 |
| WB Predicted band size | 27kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | Purified recombinant fragment of human CEACAM3 (AA: 35-155) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于Tyrosine Hydroxylase (Phospho-Ser31)抗体的3篇典型参考文献示例(内容为模拟，仅供参考)：
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1. **文献名称**: *Phosphorylation of Tyrosine Hydroxylase at Ser31 modulates dopamine biosynthesis in vivo*
**作者**: Haycock, J.W. et al.
**摘要**: 研究证实Ser31位点的磷酸化通过增强TH酶活性调控多巴胺合成，利用Phospho-Ser31特异性抗体在小鼠脑组织中发现该修饰与急性应激反应相关。
2. **文献名称**: *Regulation of Tyrosine Hydroxylase phosphorylation by MAPK/ERK in dopaminergic neurons*
**作者**: Kumer, S.C. & Halterman, C.
**摘要**: 通过免疫印迹和免疫组化(使用Phospho-Ser31抗体)证明，ERK激酶介导的Ser31磷酸化在帕金森病模型中上调，可能参与神经元存活和代偿性神经递质合成。
3. **文献名称**: *Differential phosphorylation of tyrosine hydroxylase in Parkinson's disease and addiction models*
**作者**: Nagatsu, T. et al.
**摘要**: 利用Phospho-Ser31抗体对比分析发现，帕金森动物模型黑质区TH的Ser31磷酸化水平显著降低，提示其作为疾病病理标志物的潜力。
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**注**：以上文献信息为示例，实际引用需以真实发表的论文为准。建议通过PubMed或Google Scholar搜索关键词“Tyrosine Hydroxylase Ser31 phosphorylation antibody”获取最新文献。
Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis, catalyzing the conversion of L-tyrosine to L-DOPA. Its activity is tightly regulated by phosphorylation at specific serine residues, including Ser31. which enhances enzyme stability and dopamine production under physiological or stress conditions. The phosphorylation of Ser31 is mediated by extracellular signal-regulated kinases (ERK1/2) or other kinases, linking TH activity to cellular signaling pathways.
Antibodies targeting Tyrosine Hydroxylase (Phospho-Ser31) are critical tools for studying TH regulation in dopaminergic and noradrenergic systems. These antibodies specifically recognize the phosphorylated form of TH at Ser31. enabling researchers to investigate post-translational modifications influencing catecholamine synthesis. Applications include Western blotting, immunohistochemistry, and immunofluorescence to assess TH activation in neurological disorders (e.g., Parkinson’s disease), psychiatric conditions, or stress responses. Such antibodies help clarify how kinase pathways modulate TH function, offering insights into disease mechanisms or therapeutic targets. Validation often involves testing in phosphorylated vs. non-phosphorylated protein samples to ensure specificity.
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