Rabbit Polyclonal Kv2.1(Phospho-Ser805) Antibody

中文名： Kv2.1 (Phospho-Ser805)抗体
别名： DRK1; KCB1; KCNB1; Potassium channel Kv2.1; Potassium voltage-gated channel subfamily B member 1

货号: IPDX40563

Price： ￥1280

50μl 100μl

数量：

大包装询价

验证与应用

应用及物种

WB	咨询技术	Human,Mouse,Rat
IF	咨询技术	Human,Mouse,Rat
IHC	咨询技术	Human,Mouse,Rat
ICC	技术咨询	Human,Mouse,Rat
FCM	咨询技术	Human,Mouse,Rat
Elisa	咨询技术	Human,Mouse,Rat

产品详情

Aliases	DRK1; KCB1; KCNB1; Potassium channel Kv2.1; Potassium voltage-gated channel subfamily B member 1
Entrez GeneID	3745;
WB Predicted band size	96kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Peptide sequence around phosphorylation site of serine805(P-T-S(p)-P-K) derived from Human Kv2.1 .
Formulation	Purified antibody in PBS with 0.05% sodium azide.

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Western blot analysis of extracts from K562 cells treated with TNF using Phospho-Kv2.1 (Ser805) antibody P40563.The lane on the right is treated with the antigen-specific peptide.

参考文献

以下是3条关于Kv2.1 (Phospho-Ser805)抗体的参考文献(内容基于模拟生成，供参考)：

1. **文献名称**：*Activity-dependent phosphorylation of Kv2.1 modulates neuronal excitability*

**作者**：Park KS, et al.

**摘要**：研究利用Phospho-Ser805抗体揭示Kv2.1通道在神经元活动依赖性磷酸化中的作用，发现Ser805位点的磷酸化通过调节通道聚类影响神经元兴奋性和动作电位发放模式。

2. **文献名称**：*Regulation of Kv2.1 channel clustering by phosphorylation at Ser805*

**作者**：Misonou H, et al.

**摘要**：通过免疫荧光和Western blot(使用Phospho-Ser805抗体)，证明缺血性脑损伤中Kv2.1的Ser805磷酸化水平升高，导致通道在神经元膜上的聚类重组，并参与细胞凋亡信号通路。

3. **文献名称**：*Phosphorylation-dependent trafficking of Kv2.1 in pancreatic β-cells*

**作者**：Dai X, et al.

**摘要**：研究使用Phospho-Ser805特异性抗体发现，高血糖刺激下胰岛β细胞中Kv2.1的Ser805磷酸化增强，抑制钾离子外流并促进胰岛素分泌，揭示了该位点在代谢调控中的关键作用。

(注：以上文献信息为示例性质，实际引用请以真实文献为准。)

背景信息

The Kv2.1 (Phospho-Ser805) antibody is a specialized tool used to study the phosphorylation state of the voltage-gated potassium channel Kv2.1 at serine residue 805. Kv2.1. encoded by the *KCNB1* gene, is a delayed rectifier potassium channel critical for regulating neuronal excitability and insulin secretion in pancreatic β-cells. Phosphorylation of Kv2.1 at Ser805 is a key post-translational modification that modulates channel function, including its trafficking, clustering at the plasma membrane, and interaction with regulatory proteins. This site is targeted by kinases such as CaMKII and dephosphorylated by calcineurin, linking channel activity to calcium signaling pathways.

The antibody is widely used in neuroscience and endocrine research to investigate Kv2.1's role in physiological processes (e.g., action potential repolarization, neurosecretion) and pathological conditions (e.g., epilepsy, neurodegeneration, diabetes). By detecting phosphorylated Ser805. researchers can assess Kv2.1 regulatory dynamics under conditions like oxidative stress, ischemia, or metabolic changes. Validation typically includes Western blotting, immunohistochemistry, or immunofluorescence in cell lines or tissues with known phosphorylation status. Its specificity makes it valuable for studies exploring Kv2.1 dysregulation in disease models or pharmacological interventions targeting potassium channel modulation.