关键信息
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基因名
WIZ
- 应用
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别名
WIZ；ZNF803；Protein Wiz
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O95785
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表达区间
1228-1419aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMASMTGGQQMGRGSEFRTRCEFCGEFFENRKGLSSHARSHLRQMGVTEWSVNGSPIDTLREILKKKSKPCLIKKEPPAGDLAPALAEDGPPTVAPGPVQSPLPLSPLAGRPGKPGAGPAQVPRELSLTPITGAKPSATGYLGSVAAKRPLQEDRLLPAEVKAKTYIQTELPFKAKTLHEKTSHSSTEACCELCGLYFENRKALASHARAH
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分子量
28.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
WIZ (Wiz, the putative zinc-finger protein) is a protein that has garnered attention in recent years due to its potential roles in cellular processes such as differentiation, proliferation, and apoptosis. Research indicates that WIZ may function as a transcriptional regulator, influencing gene expression through its interaction with various chromatin-modifying complexes. The restructuring of WIZ protein has become a focal point in understanding its functional mechanisms, especially concerning its involvement in various biological pathways and diseases, including cancer. Given the rising incidence of malignancies linked to aberrant cellular signaling and gene regulation, understanding the intricate role of WIZ can pave the way for novel therapeutic strategies. Investigations into the structural and functional aspects of WIZ are crucial, as they may reveal targets for pharmacological intervention. Moreover, the study of WIZ-recombinant proteins in cellular models can provide insights into how alterations in WIZ function contribute to disease pathogenesis, thereby highlighting its potential as a biomarker for cancer prognosis. Overall, dissecting the molecular workings of WIZ not only enhances our knowledge of fundamental biological processes but also offers promising avenues for developing targeted treatments in oncology and other related fields.
