| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MAX;bHLHd4 |
| Entrez GeneID | 4149 |
| WB Predicted band size | 21kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic phosphorylated peptide around S11 of human MAX (NP_002373.3). |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MAX(Phospho-Ser11)抗体的3篇示例参考文献(注：以下文献为模拟示例，实际文献需通过数据库检索确认)：
1. **文献名称**：*"Phosphorylation of MAX at Ser11 Modulates DNA Damage Response in Cancer Cells"*
**作者**：Chen L, et al.
**摘要**：本研究揭示了MAX蛋白Ser11位点的磷酸化在DNA损伤应答中的作用，通过使用特异性MAX(Phospho-Ser11)抗体，证实其在ATM/ATR激酶通路中的调控机制，并发现该修饰影响MYC/MAX复合物的转录活性。
2. **文献名称**：*"Dynamic Regulation of MAX Phosphorylation in Cell Cycle Progression"*
**作者**：Saito K, et al.
**摘要**：通过Western blot和免疫荧光技术结合MAX(Phospho-Ser11)抗体，作者发现Ser11磷酸化水平在G1/S期转换时显著升高，并与CDK2激酶活性相关，提示其在细胞周期调控中的潜在功能。
3. **文献名称**：*"Phospho-Ser11 MAX as a Biomarker for MYC-Driven Tumorigenesis"*
**作者**：Wang H, et al.
**摘要**：该研究利用MAX(Phospho-Ser11)抗体检测多种肿瘤样本，发现Ser11磷酸化水平与MYC过表达呈正相关，且高磷酸化状态预示患者预后不良，为MYC依赖性肿瘤提供了新生物标志物。
如需实际文献，建议通过PubMed或Web of Science以关键词“MAX Phospho-Ser11 antibody”或“MAX Ser11 phosphorylation”检索近期研究。
The MAX (Phospho-Ser11) antibody is a specialized tool used to study the phosphorylation status of the MAX protein at serine residue 11 (Ser11). MAX, a member of the basic helix-loop-helix leucine zipper (bHLH-ZIP) family, forms heterodimers with MYC transcription factors to regulate gene expression involved in cell proliferation, differentiation, and apoptosis. Phosphorylation at specific residues, including Ser11. modulates MAX's interactions with MYC or other partners, influencing transcriptional activity and cellular outcomes.
The Ser11 phosphorylation event is linked to regulatory mechanisms in DNA damage response, cell cycle control, and oncogenic signaling. For example, DNA damage kinases may phosphorylate MAX at Ser11 to alter its stability or subcellular localization, impacting MYC/MAX-driven transcriptional programs. Dysregulation of this pathway is implicated in cancers, where MYC overexpression is common. The MAX (Phospho-Ser11) antibody enables detection of this post-translational modification in techniques like Western blotting, immunofluorescence, or immunoprecipitation, aiding research into MYC/MAX network dynamics.
Validation often includes testing in phosphorylation-deficient mutants or phosphatase-treated samples to confirm specificity. Researchers use this antibody to explore context-dependent phosphorylation patterns in disease models, drug response studies, or mechanistic analyses of MAX-related signaling cascades. Proper controls and optimized experimental conditions are critical due to potential cross-reactivity or low endogenous phosphorylation levels.
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