| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/40000 | Human,Mouse,Rat |
| Aliases | EFNA4; EPLG4; LERK4; Ephrin-A4; EPH-related receptor tyrosine kinase ligand 4; LERK-4 |
| Entrez GeneID | 1945; |
| WB Predicted band size | 95kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from the C-terminal region of human Ephrin-A4. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于Ephrin-A4抗体的3篇代表性文献的简要总结(文献标题和作者为虚构示例，供参考)：
1. **标题**：Ephrin-A4 Antibody Inhibits Tumor Angiogenesis in Colorectal Cancer Models
**作者**：Smith J, et al.
**摘要**：研究证明，Ephrin-A4抗体通过阻断EphA受体介导的信号通路，显著抑制结直肠癌小鼠模型中肿瘤血管生成，降低肿瘤生长和转移。
2. **标题**：Ephrin-A4 Neutralizing Antibody Attenuates Neuroinflammatory Responses
**作者**：Chen L, et al.
**摘要**：该文献发现，Ephrin-A4抗体可通过调节小胶质细胞活化，减轻实验性自身免疫性脑脊髓炎(EAE)模型中的神经炎症反应，提示其治疗神经退行性疾病的潜力。
3. **标题**：Targeting Ephrin-A4 with a Monoclonal Antibody Enhances Axonal Regeneration
**作者**：Wang Y, et al.
**摘要**：开发了一种靶向Ephrin-A4的单克隆抗体，实验显示其能促进脊髓损伤后轴突再生并改善运动功能，机制涉及抑制EphA4受体的反向信号传导。
(注：以上为模拟内容，实际文献需通过PubMed/Google Scholar等平台搜索关键词“Ephrin-A4 antibody”获取。)
Ephrin-A4. a member of the Ephrin family of membrane-bound proteins, plays a critical role in cell-cell communication by interacting with Eph receptors, part of the largest receptor tyrosine kinase family. As a glycosylphosphatidylinositol (GPI)-anchored ligand, Ephrin-A4 primarily binds to EphA receptors, triggering bidirectional signaling pathways that regulate diverse biological processes, including cell adhesion, migration, tissue patterning, and angiogenesis. Dysregulation of Ephrin-A4-EphA signaling is implicated in pathological conditions such as cancer metastasis, inflammatory diseases, and neurological disorders.
Ephrin-A4 antibodies are immunological tools designed to specifically target and modulate Ephrin-A4 activity. These antibodies are utilized in research to study Ephrin-A4's functional roles, localization, and interaction networks in both normal and diseased states. In cancer biology, Ephrin-A4 antibodies help investigate tumor microenvironment interactions, metastasis mechanisms, and potential therapeutic targeting. Additionally, they are explored for diagnostic applications, as Ephrin-A4 overexpression correlates with aggressive tumor behavior in certain cancers.
The development of therapeutic Ephrin-A4 antibodies faces challenges, including optimizing specificity to avoid off-target effects and ensuring efficient tissue penetration. Nonetheless, their potential to disrupt pathological Ephrin-A4 signaling pathways makes them promising candidates for targeted therapies, particularly in oncology and inflammatory diseases. Ongoing research aims to refine antibody engineering and evaluate preclinical efficacy to advance translational applications.
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