| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/20000 | Human,Mouse,Rat |
| Aliases | TUBGCP5; GCP5; KIAA1899; Gamma-tubulin complex component 5; GCP-5 |
| Entrez GeneID | 114791; |
| WB Predicted band size | 118kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from the Internal region of human GCP5. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于GCP5抗体的3篇参考文献及其摘要(内容基于公开研究框架虚构，仅供参考)：
1. **标题**：**"GCP5作为γ-微管蛋白复合体核心组分的功能研究"**
**作者**：Zheng Y. et al.
**摘要**：该研究解析了GCP5在γ-微管蛋白复合体(γ-TuRC)中的结构作用，通过特异性抗体证实其与微管成核的关联，并发现GCP5缺失会导致细胞分裂异常。
2. **标题**：**"GCP5在非小细胞肺癌中的过表达及靶向治疗潜力"**
**作者**：Smith J. et al.
**摘要**：利用GCP5抗体进行免疫组化分析，发现GCP5在肺癌组织中显著高表达;体外实验表明，靶向GCP5的抗体可抑制肿瘤细胞增殖并增强化疗敏感性。
3. **标题**：**"基于GCP5抗体的微管动态定量检测方法开发"**
**作者**：Lee H. et al.
**摘要**：研究团队开发了一种基于GCP5抗体的高灵敏度免疫荧光技术，用于实时追踪活细胞中微管动态变化，为药物筛选提供了新工具。
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*注：以上文献为示例性质，实际研究中建议通过PubMed/Google Scholar以“GCP5 antibody”或“γ-tubulin complex component 5”为关键词检索最新论文。*
GCP5 (Gamma-tubulin Complex Component 5) is a critical protein within the γ-tubulin ring complex (γ-TuRC), a multi-subunit assembly essential for microtubule nucleation in eukaryotic cells. As part of γ-TuRC, GCP5 helps anchor microtubule-organizing centers (MTOCs), such as centrosomes, to initiate and regulate microtubule growth. This process underpins cell division, intracellular transport, and maintenance of cell shape. Dysregulation of GCP5 has been implicated in pathological conditions, including cancers, where its overexpression correlates with enhanced cell proliferation, genomic instability, and poor prognosis. In neurological disorders, aberrant GCP5 function may disrupt neuronal microtubule dynamics, contributing to neurodegeneration.
Antibodies targeting GCP5 are vital tools for studying its expression, localization, and interactions within γ-TuRC. They enable techniques like immunofluorescence, Western blotting, and co-immunoprecipitation to explore GCP5's role in cellular processes and disease mechanisms. Additionally, GCP5 antibodies have potential diagnostic and therapeutic applications, particularly in cancer research, where they may aid in identifying biomarkers or developing targeted therapies. Recent studies also investigate their utility in elucidating mechanisms of chemoresistance, as microtubule-targeting drugs (e.g., taxanes) rely on functional γ-TuRC activity. Ongoing research continues to refine GCP5 antibody specificity and applications, advancing understanding of microtubule biology and related pathologies.
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