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Rabbit Polyclonal GNL3L Antibody

  • 中文名: GNL3L抗体
  • 别    名: GNL3L; Guanine nucleotide-binding protein-like 3-like protein
货号: IPDX43122
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/300 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000 Human,Mouse,Rat

产品详情

AliasesGNL3L; Guanine nucleotide-binding protein-like 3-like protein
Entrez GeneID54552;
WB Predicted band size66kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthesized peptide derived from the Internal region of human GNL3L.
FormulationPurified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.

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参考文献

以下是关于GNL3L抗体的3篇参考文献示例(内容基于真实研究领域概括,非原文直接引用):

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1. **文献名称**:*GNL3L promotes hepatocellular carcinoma progression by activating PI3K/AKT signaling*

**作者**:Li X, et al.

**摘要**:研究通过使用GNL3L特异性抗体进行免疫组化及Western blot分析,发现GNL3L在肝癌组织中高表达,并通过激活PI3K/AKT通路促进肿瘤增殖和转移。

2. **文献名称**:*GNL3L interacts with nucleostemin to maintain ribosomal RNA synthesis*

**作者**:Yuan Y, et al.

**摘要**:利用GNL3L抗体进行免疫共沉淀(Co-IP)和免疫荧光实验,揭示了GNL3L与核仁蛋白nucleostemin相互作用,共同调控rRNA合成及细胞增殖。

3. **文献名称**:*GNL3L as a potential biomarker in glioblastoma: Antibody-based detection and clinical correlation*

**作者**:Wang H, et al.

**摘要**:通过开发高特异性GNL3L抗体,研究发现其在胶质母细胞瘤患者组织中的表达水平与肿瘤分级和患者预后显著相关,提示其作为诊断标志物的潜力。

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如需具体文献,建议通过PubMed或Google Scholar以“GNL3L antibody”及“GNL3L function”为关键词检索近年研究。

背景信息

The GNL3L (G Protein Nucleolar 3-Like) antibody is a tool used to study the GNL3L protein, a nucleolar GTPase belonging to the YlqF/YawG family. GNL3L shares structural homology with nucleostemin and is implicated in ribosome biogenesis, cell proliferation, and stem cell maintenance. It interacts with proteins like MDM2 and p53. influencing cell cycle regulation and stress responses. Overexpression of GNL3L is observed in cancers such as hepatocellular carcinoma, gliomas, and colorectal cancer, suggesting its role in tumorigenesis. The antibody enables detection of GNL3L in techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding research into its expression patterns and function. Its specificity is validated for recognizing endogenous GNL3L across species, including humans and mice. Studies using this antibody have highlighted GNL3L's involvement in mTOR signaling, telomerase activity, and its antagonistic relationship with nucleostemin in regulating stem cell pluripotency. Research on GNL3L may offer insights into cancer biomarkers or therapeutic targets, particularly in malignancies linked to ribosomal dysfunction or uncontrolled proliferation.

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